Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts - PubMed (original) (raw)

Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts

P Merville et al. J Exp Med. 1996.

Abstract

Plasma cells represent the final stage of B lymphocyte differentiation. Most plasma cells in secondary lymphoid tissues live for a few days, whereas those in the lamina propria of mucosa and in bone marrow live for several weeks. To investigate the regulation of human plasma cell survival, plasma cells were isolated from tonsils according to high CD38 and low CD20 expression. Tonsillar plasma cells express CD9, CD19, CD24, CD37, CD40, CD74, and HLA-DR, but not CD10, HLA-DQ, CD28, CD56, and Fas/CD95. Although plasma cells express intracytoplasmic Bcl-2, they undergo swift apoptosis in vitro and do not respond to CD40 triggering. Bone marrow fibroblasts and rheumatoid synoviocytes, however, prevented plasma cells from undergoing apoptosis in a contact-dependent fashion. These data indicate that fibroblasts may form a microenvironment favorable for plasma cell survival under normal and pathological conditions.

PubMed Disclaimer

Similar articles

• CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations.
  Arce S, Luger E, Muehlinghaus G, Cassese G, Hauser A, Horst A, Lehnert K, Odendahl M, Hönemann D, Heller KD, Kleinschmidt H, Berek C, Dörner T, Krenn V, Hiepe F, Bargou R, Radbruch A, Manz RA. Arce S, et al. J Leukoc Biol. 2004 Jun;75(6):1022-8. doi: 10.1189/jlb.0603279. Epub 2004 Mar 12. J Leukoc Biol. 2004. PMID: 15020647
• The CD24 antigen discriminates between pre-B and B cells in human bone marrow.
  Duperray C, Boiron JM, Boucheix C, Cantaloube JF, Lavabre-Bertrand T, Attal M, Brochier J, Maraninchi D, Bataille R, Klein B. Duperray C, et al. J Immunol. 1990 Dec 1;145(11):3678-83. J Immunol. 1990. PMID: 1700990
• Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.
  Martinez-Valdez H, Guret C, de Bouteiller O, Fugier I, Banchereau J, Liu YJ. Martinez-Valdez H, et al. J Exp Med. 1996 Mar 1;183(3):971-7. doi: 10.1084/jem.183.3.971. J Exp Med. 1996. PMID: 8642300 Free PMC article.
• Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule.
  Lagresle C, Bella C, Daniel PT, Krammer PH, Defrance T. Lagresle C, et al. J Immunol. 1995 Jun 1;154(11):5746-56. J Immunol. 1995. PMID: 7538529
• Isolation, maturational level, and functional capacity of human colon lamina propria plasma cells.
  Medina F, Segundo C, Campos-Caro A, Salcedo I, García-Poley A, Brieva JA. Medina F, et al. Gut. 2003 Mar;52(3):383-9. doi: 10.1136/gut.52.3.383. Gut. 2003. PMID: 12584220 Free PMC article.

Cited by

• Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ-on-a-Chip.
  Goyal G, Prabhala P, Mahajan G, Bausk B, Gilboa T, Xie L, Zhai Y, Lazarovits R, Mansour A, Kim MS, Patil A, Curran D, Long JM, Sharma S, Junaid A, Cohen L, Ferrante TC, Levy O, Prantil-Baun R, Walt DR, Ingber DE. Goyal G, et al. Adv Sci (Weinh). 2022 May;9(14):e2103241. doi: 10.1002/advs.202103241. Epub 2022 Mar 14. Adv Sci (Weinh). 2022. PMID: 35289122 Free PMC article.
• Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells.
  Pascual-Reguant A, Köhler R, Mothes R, Bauherr S, Hernández DC, Uecker R, Holzwarth K, Kotsch K, Seidl M, Philipsen L, Müller W, Romagnani C, Niesner R, Hauser AE. Pascual-Reguant A, et al. Nat Commun. 2021 Mar 19;12(1):1737. doi: 10.1038/s41467-021-21994-8. Nat Commun. 2021. PMID: 33741932 Free PMC article.
• The transcriptional profiling of human in vivo-generated plasma cells identifies selective imbalances in monoclonal gammopathies.
  Valor LM, Rodríguez-Bayona B, Ramos-Amaya AB, Brieva JA, Campos-Caro A. Valor LM, et al. PLoS One. 2017 Aug 17;12(8):e0183264. doi: 10.1371/journal.pone.0183264. eCollection 2017. PLoS One. 2017. PMID: 28817638 Free PMC article.
• The Fas/CD95 Receptor Regulates the Death of Autoreactive B Cells and the Selection of Antigen-Specific B Cells.
  Koncz G, Hueber AO. Koncz G, et al. Front Immunol. 2012 Jul 25;3:207. doi: 10.3389/fimmu.2012.00207. eCollection 2012. Front Immunol. 2012. PMID: 22848207 Free PMC article.
• Pancreatic ductal adenocarcinoma: a review of immunologic aspects.
  Wachsmann MB, Pop LM, Vitetta ES. Wachsmann MB, et al. J Investig Med. 2012 Apr;60(4):643-63. doi: 10.2310/JIM.0b013e31824a4d79. J Investig Med. 2012. PMID: 22406516 Free PMC article. Review.

References

1. 1. Blood. 1993 May 15;81(10):2658-63 - PubMed
2. 1. J Exp Med. 1995 Nov 1;182(5):1265-73 - PubMed
3. 1. J Exp Med. 1990 Dec 1;172(6):1873-6 - PubMed
4. 1. J Immunol. 1988 Jan 15;140(2):354-60 - PubMed
5. 1. J Immunol. 1983 Jul;131(1):244-50 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Ovid Technologies, Inc.
  • PubMed Central
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal