Anorectal function in fluctuating (on-off) Parkinson's disease: evaluation by combined anorectal manometry and electromyography - PubMed (original) (raw)
Anorectal function in fluctuating (on-off) Parkinson's disease: evaluation by combined anorectal manometry and electromyography
W Ashraf et al. Mov Disord. 1995 Sep.
Abstract
Anorectal dysfunction and constipation are well recognized in Parkinson's disease and may reflect the direct involvement of the gastrointestinal tract by the primary Parkinson's disease process. We hypothesized, therefore, that anorectal function would alter in parallel with fluctuations in motor function related to on- and off-periods in Parkinson's disease, and employed combined anorectal manometry and electromyography to investigate anorectal function during both on- and off-periods in patients with Parkinson's disease. Manometric recordings revealed a deterioration in voluntary sphincter squeeze during off-periods (squeeze index, on versus off, mean +/- SEM: 46.4 +/- 11.1 versus 29.6 +/- 7.9 mm Hg, p < 0.05); correspondingly, simultaneous electromyographic (EMG) recordings showed poor recruitment of external anal sphincter and puborectalis muscles during off-periods. A hypercontractile ("paradoxical") rectosphincteric reflex response occurred during both on- and off-periods, and was associated with an increase in EMG activity in the external sphincter and/or the puborectalis muscle. These changes in manometric and EMG parameters paralleled changes in overall motor function. These findings provide further support for the involvement of the pelvic floor musculature in the Parkinson's disease process and also provide EMG correlates for some of the manometric abnormalities described in Parkinson's disease.
Similar articles
- Anorectal manometry in the assessment of anorectal function in Parkinson's disease: a comparison with chronic idiopathic constipation.
Ashraf W, Pfeiffer RF, Quigley EM. Ashraf W, et al. Mov Disord. 1994 Nov;9(6):655-63. doi: 10.1002/mds.870090612. Mov Disord. 1994. PMID: 7845407 - Characterization of swallowing and defecation in Parkinson's disease.
Edwards LL, Quigley EM, Harned RK, Hofman R, Pfeiffer RF. Edwards LL, et al. Am J Gastroenterol. 1994 Jan;89(1):15-25. Am J Gastroenterol. 1994. PMID: 8273792 - Defecatory function in Parkinson's disease: response to apomorphine.
Edwards LL, Quigley EM, Harned RK, Hofman R, Pfeiffer RF. Edwards LL, et al. Ann Neurol. 1993 May;33(5):490-3. doi: 10.1002/ana.410330512. Ann Neurol. 1993. PMID: 8498826 - Gastrointestinal dysfunction in Parkinson's disease.
Pfeiffer RF. Pfeiffer RF. Parkinsonism Relat Disord. 2011 Jan;17(1):10-5. doi: 10.1016/j.parkreldis.2010.08.003. Epub 2010 Sep 15. Parkinsonism Relat Disord. 2011. PMID: 20829091 Review. - Gastrointestinal dysfunction in Parkinson's disease.
Quigley EM. Quigley EM. Semin Neurol. 1996 Sep;16(3):245-50. doi: 10.1055/s-2008-1040981. Semin Neurol. 1996. PMID: 9085474 Review.
Cited by
- Parkinson Disease-Mediated Gastrointestinal Disorders and Rational for Combinatorial Therapies.
Ali SA, Yin N, Rehman A, Justilien V. Ali SA, et al. Med Sci (Basel). 2016 Jan 20;4(1):1. doi: 10.3390/medsci4010001. Med Sci (Basel). 2016. PMID: 29083365 Free PMC article. Review. - Bladder, bowel, and sexual dysfunction in Parkinson's disease.
Sakakibara R, Kishi M, Ogawa E, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T. Sakakibara R, et al. Parkinsons Dis. 2011;2011:924605. doi: 10.4061/2011/924605. Epub 2011 Sep 12. Parkinsons Dis. 2011. PMID: 21918729 Free PMC article. - Nonmotor symptoms in a malaysian Parkinson's disease population.
Azmin S, Khairul Anuar AM, Tan HJ, Nafisah WY, Raymond AA, Hanita O, Shah SA, Norlinah MI. Azmin S, et al. Parkinsons Dis. 2014;2014:472157. doi: 10.1155/2014/472157. Epub 2014 Apr 1. Parkinsons Dis. 2014. PMID: 24800102 Free PMC article. - Parkinson's Disease and the Gut: Symptoms, Nutrition, and Microbiota.
Yemula N, Dietrich C, Dostal V, Hornberger M. Yemula N, et al. J Parkinsons Dis. 2021;11(4):1491-1505. doi: 10.3233/JPD-212707. J Parkinsons Dis. 2021. PMID: 34250955 Free PMC article. Review. - Gastrointestinal dysfunction in the synucleinopathies.
Chung KA, Pfeiffer RF. Chung KA, et al. Clin Auton Res. 2021 Feb;31(1):77-99. doi: 10.1007/s10286-020-00745-7. Epub 2020 Nov 27. Clin Auton Res. 2021. PMID: 33247399 Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical