Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein - PubMed (original) (raw)

. 1996 Jan 25;379(6563):343-6.

doi: 10.1038/379343a0.

K Gijbels, M Allegretta, I Ferber, C Piercy, T Blankenstein, R Martin, U Utz, N Karin, D Mitchell, T Veromaa, A Waisman, A Gaur, P Conlon, N Ling, P J Fairchild, D C Wraith, A O'Garra, C G Fathman, L Steinman

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Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

S Brocke et al. Nature. 1996.

Erratum in

Abstract

Following induction of experimental encephalomyelitis with a T-cell clone, L10C1, that is specific for the myelin basic protein epitope p87-99, the inflammatory infiltrate in the central nervous system contains a diverse collection of T cells with heterogeneous receptors. We show here that when clone L10C1 is tolerized in vivo with an analogue of p87-99, established paralysis is reversed, inflammatory infiltrates regress, and the heterogeneous T-cell infiltrate disappears from the brain, with only the T-cell clones that incited disease remaining in the original lesions. We found that antibody raised against interleukin-4 reversed the tolerance induced by the altered peptide ligand. Treatment with this altered peptide ligand selectively silences pathogenic T cells and actively signals for the efflux of other T cells recruited to the site of disease as a result of the production of interleukin-4 and the reduction of tumour-necrosis factor-alpha in the lesion.

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