Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc - PubMed (original) (raw)
. 1996 Jan;122(1):359-69.
doi: 10.1242/dev.122.1.359.
Affiliations
- PMID: 8565848
- DOI: 10.1242/dev.122.1.359
Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
J F de Celis et al. Development. 1996 Jan.
Abstract
The cells along the dorsoventral boundary of the Drosophila wing imaginal disc have distinctive properties and their specification requires Notch activity. Later in development, these cells will form the wing margin, where sensory organs and specialised trichomes appear in a characteristic pattern. We find that Notch is locally activated in these cells, as demonstrated by the restricted expression of the Enhancer of split proteins in dorsal and ventral cells abutting the D/V boundary throughout the third larval instar. Furthermore other genes identified by their involvement in Notch signaling during neurogenesis, such as Delta and Suppressor of Hairless, also participate in Notch function at the dorsoventral boundary. In addition, Serrate, a similar transmembrane protein to Delta, behaves as a ligand required in dorsal cells to activate Notch at the boundary. Notch gain-of-function alleles in which Notch activity is not restricted to the dorsoventral boundary cause miss-expression of cut and wingless and overgrowth of the disc, illustrating the importance of localised Notch activation for wing development.
Similar articles
- Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.
Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN. Doherty D, et al. Genes Dev. 1996 Feb 15;10(4):421-34. doi: 10.1101/gad.10.4.421. Genes Dev. 1996. PMID: 8600026 - Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing.
de Celis JF, Bray S. de Celis JF, et al. Development. 1997 Sep;124(17):3241-51. doi: 10.1242/dev.124.17.3241. Development. 1997. PMID: 9310319 - A dominant-negative form of Serrate acts as a general antagonist of Notch activation.
Hukriede NA, Gu Y, Fleming RJ. Hukriede NA, et al. Development. 1997 Sep;124(17):3427-37. doi: 10.1242/dev.124.17.3427. Development. 1997. PMID: 9310337 - Sequential Notch signalling at the boundary of fringe expressing and non-expressing cells.
Troost T, Klein T. Troost T, et al. PLoS One. 2012;7(11):e49007. doi: 10.1371/journal.pone.0049007. Epub 2012 Nov 12. PLoS One. 2012. PMID: 23152840 Free PMC article.
Cited by
- Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion.
White MJ, Jacobs KA, Singh T, Mayo LN, Lin A, Chen CS, Jun YW, Kutys ML. White MJ, et al. J Cell Biol. 2023 Dec 4;222(12):e202303013. doi: 10.1083/jcb.202303013. Epub 2023 Oct 5. J Cell Biol. 2023. PMID: 37796194 Free PMC article. - Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.
Chen Y, Li H, Yi TC, Shen J, Zhang J. Chen Y, et al. Int J Mol Sci. 2023 Sep 13;24(18):14028. doi: 10.3390/ijms241814028. Int J Mol Sci. 2023. PMID: 37762331 Free PMC article. Review. - TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc.
Rosales-Vega M, Reséndez-Pérez D, Zurita M, Vázquez M. Rosales-Vega M, et al. Sci Rep. 2023 Sep 13;13(1):15162. doi: 10.1038/s41598-023-42169-z. Sci Rep. 2023. PMID: 37704704 Free PMC article. - Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion.
White MJ, Jacobs KA, Singh T, Kutys ML. White MJ, et al. bioRxiv [Preprint]. 2023 Jan 23:2023.01.23.524428. doi: 10.1101/2023.01.23.524428. bioRxiv. 2023. PMID: 36747830 Free PMC article. Updated. Preprint. - Notch Missense Mutations in Drosophila Reveal Functions of Specific EGF-like Repeats in Notch Folding, Trafficking, and Signaling.
Nurmahdi H, Hasegawa M, Mujizah EY, Sasamura T, Inaki M, Yamamoto S, Yamakawa T, Matsuno K. Nurmahdi H, et al. Biomolecules. 2022 Nov 25;12(12):1752. doi: 10.3390/biom12121752. Biomolecules. 2022. PMID: 36551180 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases