Endothelin-1 and its receptor in hypertrophic cardiomyopathy - PubMed (original) (raw)

Comparative Study

doi: 10.1161/01.hyp.27.2.259.

H Fujiwara, M Koshiji, T Inada, S Ohtani, K Doyama, M Tanaka, A Matsumori, T Fujiwara, G Shirakami, K Hosoda, K Nakao, S Sasayama

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Comparative Study

Endothelin-1 and its receptor in hypertrophic cardiomyopathy

K Hasegawa et al. Hypertension. 1996 Feb.

Abstract

Endothelin-1, a potent vasoconstrictor produced by vascular endothelial cells, activates the hypertrophic program in cultured heart muscle cells. However, the role of endothelin-1 in cardiac hypertrophy in humans is unknown. Therefore, we studied hypertrophic cardiomyopathy patients with normal pulmonary arterial pressure, in whom cardiac hypertrophy is a specific feature of the disease. Radioimmunoassay with a monoclonal antibody to human endothelin-1 showed that the plasma level of immunoreactive endothelin was more than twofold higher in hypertrophic cardiomyopathy patients than in control subjects (P < .005). In situ hybridization analysis of endomyocardial biopsy specimens showed positive signals of endothelin-1 type A receptor mRNA in ventricular myocytes of all specimens. The receptor expression in ventricular myocytes was similar between hypertrophic cardiomyopathy patients and control subjects. We propose that endothelin-1 might represent an important factor involved in hypertrophic cardiomyopathy. Whether endothelin-1 plays a causal role in cardiac hypertrophy or is a marker of its occurrence needs to be clarified.

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