Low versus high cell turnover in diffusely growing non-Hodgkin's lymphomas - PubMed (original) (raw)
Low versus high cell turnover in diffusely growing non-Hodgkin's lymphomas
D Spina et al. J Pathol. 1995 Dec.
Abstract
Cell loss, perhaps as important as cell production in determining the size of an expanding cell population, has not usually been registered in quantitative cellular kinetic analyses of neoplastic disorders. The present retrospective study on various types and subtypes of non-Hodgkin's lymphomas (NHLs; n = 170) was designed to test the usefulness of a novel additional parameter, the 'turnover index' (TI), which is the sum per case of the mitotic index and the apoptotic index. Results document that TIs clearly distinguished between categories and subtypes of NHLs according to the Kiel classification. Cluster analysis of TIs plotted against the percentage of Ki-67-positive cells per case revealed that about one-third of the high-grade malignancy lymphomas actually belonged to the low-turnover lymphomas. Overall survival was longer in the low- than in the high-turnover group of lymphomas. Assessment of TIs can, for practical diagnostic purposes, be replaced by counting mitotic figures and apoptotic cells in several high-power fields. The TI concept may help to interpret the kinetics of NHLs in terms of accumulation vs. proliferation of cells.
Comment in
- Turnover index--a predictor of 'tumour' progression at presentation?
Naresh KN. Naresh KN. J Pathol. 1996 Nov;180(3):349-50. doi: 10.1002/(SICI)1096-9896(199611)180:3<349::AID-PATH665>3.0.CO;2-#. J Pathol. 1996. PMID: 8958818 No abstract available. - Low versus high cell turnover in diffusely growing non-Hodgkin's lymphomas.
Yavorkovsky LL. Yavorkovsky LL. J Pathol. 1996 Nov;180(3):350-1. doi: 10.1002/(SICI)1096-9896(199611)180:3<350::AID-PATH666>3.0.CO;2-2. J Pathol. 1996. PMID: 8958819 No abstract available.
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