Action at a distance: DNA-looping and initiation of transcription - PubMed (original) (raw)
Review
Action at a distance: DNA-looping and initiation of transcription
K Rippe et al. Trends Biochem Sci. 1995 Dec.
Abstract
Effective initiation of transcription, especially in eukaryotes, requires the specific assembly of large protein complexes at promoters. We ask here how activator proteins that are bound hundreds or thousands of base pairs away from the promoter might facilitate this process if protein-protein interactions occur via looping of the intervening DNA. We show that the local concentration at the promoter of activator proteins bound at vicinal DNA sites can be substantially regulated by intrinsic or protein-induced distortion of the regular DNA conformation.
Similar articles
- Making contacts on a nucleic acid polymer.
Rippe K. Rippe K. Trends Biochem Sci. 2001 Dec;26(12):733-40. doi: 10.1016/s0968-0004(01)01978-8. Trends Biochem Sci. 2001. PMID: 11738597 Review. - Transcription regulation by inflexibility of promoter DNA in a looped complex.
Choy HE, Park SW, Parrack P, Adhya S. Choy HE, et al. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7327-31. doi: 10.1073/pnas.92.16.7327. Proc Natl Acad Sci U S A. 1995. PMID: 7638190 Free PMC article. - DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1.
Su W, Jackson S, Tjian R, Echols H. Su W, et al. Genes Dev. 1991 May;5(5):820-6. doi: 10.1101/gad.5.5.820. Genes Dev. 1991. PMID: 1851121 - Lymphoid enhancer binding factor 1 regulates transcription through gene looping.
Yun K, So JS, Jash A, Im SH. Yun K, et al. J Immunol. 2009 Oct 15;183(8):5129-37. doi: 10.4049/jimmunol.0802744. Epub 2009 Sep 25. J Immunol. 2009. PMID: 19783677 - Multiprotein-DNA complexes in transcriptional regulation.
Wolberger C. Wolberger C. Annu Rev Biophys Biomol Struct. 1999;28:29-56. doi: 10.1146/annurev.biophys.28.1.29. Annu Rev Biophys Biomol Struct. 1999. PMID: 10410794 Review.
Cited by
- Structure-driven homology pairing of chromatin fibers: the role of electrostatics and protein-induced bridging.
Cherstvy AG, Teif VB. Cherstvy AG, et al. J Biol Phys. 2013 Jun;39(3):363-85. doi: 10.1007/s10867-012-9294-4. Epub 2013 Jan 17. J Biol Phys. 2013. PMID: 23860914 Free PMC article. - Multiple transcription-activating sequences regulate the RsmZ regulatory small RNA of Pseudomonas brassicacearum.
Lalaouna D, Fochesato S, Barakat M, Ortet P, Achouak W. Lalaouna D, et al. J Bacteriol. 2012 Sep;194(18):4888-93. doi: 10.1128/JB.00408-12. Epub 2012 Jul 6. J Bacteriol. 2012. PMID: 22773788 Free PMC article. - Dynamics of site juxtaposition in supercoiled DNA.
Huang J, Schlick T, Vologodskii A. Huang J, et al. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):968-73. doi: 10.1073/pnas.98.3.968. Proc Natl Acad Sci U S A. 2001. PMID: 11158579 Free PMC article. - Looping charged elastic rods: applications to protein-induced DNA loop formation.
Cherstvy AG. Cherstvy AG. Eur Biophys J. 2011 Jan;40(1):69-80. doi: 10.1007/s00249-010-0628-5. Epub 2010 Oct 21. Eur Biophys J. 2011. PMID: 20963409 - Interconvertible lac repressor-DNA loops revealed by single-molecule experiments.
Wong OK, Guthold M, Erie DA, Gelles J. Wong OK, et al. PLoS Biol. 2008 Sep 30;6(9):e232. doi: 10.1371/journal.pbio.0060232. PLoS Biol. 2008. PMID: 18828671 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources