Multi-copy nuclear pseudogenes of mitochondrial DNA reveal recent acute genetic changes in the human genome - PubMed (original) (raw)
Multi-copy nuclear pseudogenes of mitochondrial DNA reveal recent acute genetic changes in the human genome
G Hu et al. Curr Genet. 1995 Oct.
Abstract
Four nuclear pseudogenes homologous to the 10031-10195-bp region of the human mitochondrial genome were detected by constant denaturant capillary electrophoresis. Among them, one pseudogene is present as at least five copies in each cell, in accordance with our previous observations of multi-copy mitochondrial DNA pseudogenes. The presence of multiple identical copies of pseudogenes suggests that the human genome underwent a series of genetic changes, including gene amplifications, very recently in evolutionary history, i.e., within the last 390000 years.
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References
- Genetics. 1986 Aug;113(4):1077-91 - PubMed
- J Mol Biol. 1989 Dec 20;210(4):703-7 - PubMed
- Science. 1988 Mar 11;239(4845):1263-8 - PubMed
- Gene. 1994 Sep 30;147(2):197-204 - PubMed
- Nature. 1981 Apr 9;290(5806):457-65 - PubMed
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