Interactions between adipose tissue around lymph nodes and lymphoid cells in vitro - PubMed (original) (raw)
. 1995 Oct;36(10):2219-31.
Affiliations
- PMID: 8576648
Free article
Interactions between adipose tissue around lymph nodes and lymphoid cells in vitro
C M Pond et al. J Lipid Res. 1995 Oct.
Free article
Abstract
The functional relationships between lymphoid cells and the adipose tissue that surrounds lymph nodes were investigated in healthy adult guinea pigs. Lymphoid cells extracted from healthy adult guinea pigs were co-cultured for 48 h with adipose tissue explants from 18 sites defined by their anatomical relations to lymph nodes. Such explants from near a node suppressed lymphocyte proliferation stimulated with concanavalin A or lipopolysaccharide more than those from sites 5-10 mm from nodes. Inhibition was almost completely abolished by 500 microU insulin. The presence of lymphoid cells increased lipolysis (measured as glycerol release) in adipose tissue from all depots containing lymph nodes (i.e., except perirenal), especially in the presence of mitogens and with near-node samples from intermuscular and mesenteric depots. Inhibition of lymphocyte proliferation by adipose tissue was proportional to the additional lipolysis stimulated by the presence of lymphoid cells. For all depots except the mesenteric, glycerol release stimulated by lymphoid cells was inversely proportional to spontaneous lipolysis in adipose tissue cultured alone. These experiments demonstrate reciprocal interactions between lymphoid cells and adipose tissue, especially that around lymph nodes. The mediators of the action of adipose tissue on lymphoid cells probably include lipolytic products; mediators of the inverse effects are unknown.
Similar articles
- Site-specific differences in the action of NRTI drugs on adipose tissue incubated in vitro with lymphoid cells, and their interaction with dietary lipids.
Mattacks CA, Sadler D, Pond CM. Mattacks CA, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2003 May;135(1):11-29. doi: 10.1016/s1532-0456(03)00024-3. Comp Biochem Physiol C Toxicol Pharmacol. 2003. PMID: 12781837 - The source of fatty acids incorporated into proliferating lymphoid cells in immune-stimulated lymph nodes.
Pond CM, Mattacks CA. Pond CM, et al. Br J Nutr. 2003 Mar;89(3):375-83. doi: 10.1079/BJN2002784. Br J Nutr. 2003. PMID: 12628033 - Long-term changes in adipose tissue in human disease.
Pond CM. Pond CM. Proc Nutr Soc. 2001 Aug;60(3):365-74. doi: 10.1079/pns200198. Proc Nutr Soc. 2001. PMID: 11681811 Review. - Adipose tissue and the immune system.
Pond CM. Pond CM. Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):17-30. doi: 10.1016/j.plefa.2005.04.005. Prostaglandins Leukot Essent Fatty Acids. 2005. PMID: 15946832 Review.
Cited by
- Endotoxin-induced alterations of adipose tissue function: a pathway to bovine metabolic stress.
Chirivi M, Contreras GA. Chirivi M, et al. J Anim Sci Biotechnol. 2024 Apr 6;15(1):53. doi: 10.1186/s40104-024-01013-8. J Anim Sci Biotechnol. 2024. PMID: 38581064 Free PMC article. Review. - Imaging peripheral lymphatic dysfunction in chronic conditions.
Sevick-Muraca EM, Fife CE, Rasmussen JC. Sevick-Muraca EM, et al. Front Physiol. 2023 Mar 15;14:1132097. doi: 10.3389/fphys.2023.1132097. eCollection 2023. Front Physiol. 2023. PMID: 37007996 Free PMC article. Review. - Beyond energy balance regulation: The underestimated role of adipose tissues in host defense against pathogens.
Barthelemy J, Bogard G, Wolowczuk I. Barthelemy J, et al. Front Immunol. 2023 Mar 2;14:1083191. doi: 10.3389/fimmu.2023.1083191. eCollection 2023. Front Immunol. 2023. PMID: 36936928 Free PMC article. Review. - Lower Metabolic Potential and Impaired Metabolic Flexibility in Human Lymph Node Stromal Cells from Patients with Rheumatoid Arthritis.
de Jong TA, Semmelink JF, Denis SW, Bolt JW, Maas M, van de Sande MGH, Houtkooper RHL, van Baarsen LGM. de Jong TA, et al. Cells. 2022 Dec 20;12(1):1. doi: 10.3390/cells12010001. Cells. 2022. PMID: 36611795 Free PMC article. - Lymphatic Vascular Permeability.
Scallan JP, Jannaway M. Scallan JP, et al. Cold Spring Harb Perspect Med. 2022 Aug 15;12(8):a041274. doi: 10.1101/cshperspect.a041274. Cold Spring Harb Perspect Med. 2022. PMID: 35879102 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources