The role and amplification of the HS Alu subfamily founder gene - PubMed (original) (raw)

The role and amplification of the HS Alu subfamily founder gene

T H Shaikh et al. J Mol Evol. 1996 Jan.

Abstract

A recently identified Alu element (Leeflang et al. J. Mol. Evol. 1993, 37:559-565), referred to as the "putative founder of the HS (PV) subfamily," was found to be present at orthologous loci in the human, chimpanzee, gorilla, and gibbon lineages. The evolution of this Alu suggested that it is a source gene in the evolution of Alu family repeats for one of the most recent subfamilies, HS. We have determined that this putative founder of the HS subfamily was not present at the orthologous loci in older primates, including old world and new world monkeys. Thus, this particular Alu locus has only been responsible for the establishment of a very small subfamily of Alu sequences. We have further demonstrated that this putative founder Alu was not responsible for the de novo Alu insertion into the neurofibromatosis-1 gene of an individual causing neurofibromatosis. Our data demonstrate that although the putative founder of the HS subfamily found by Leeflang et al. (1993) probably gave rise to one of the most recent subfamilies of Alu sequences, it has not been very active in retroposition.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1993 May 11;21(9):2252 - PubMed
    1. Science. 1991 Feb 15;251(4995):753 - PubMed
    1. Mol Cell Biol. 1990 Oct;10(10):5424-32 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 May;86(10):3718-22 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11563-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources