AU-rich elements: characterization and importance in mRNA degradation - PubMed (original) (raw)
Review
AU-rich elements: characterization and importance in mRNA degradation
C Y Chen et al. Trends Biochem Sci. 1995 Nov.
Abstract
Adenylate/uridylate-rich elements (AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors and cytokines. They represent the most common determinant of RNA stability in mammalian cells. Moreover, ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines and transcription inhibitors. These observations suggest that AREs play a critical role in the regulation of gene expression during cell growth and differentiation, and in the immune response.
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