Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor - PubMed (original) (raw)
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
S C Chua Jr et al. Science. 1996.
Abstract
Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db, rat fatty (a homolog of db), and the gene encoding the OB-R are the same gene.
Comment in
- Researchers nail down leptin receptor.
Barinaga M. Barinaga M. Science. 1996 Feb 16;271(5251):913. doi: 10.1126/science.271.5251.913. Science. 1996. PMID: 8584929 No abstract available.
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