Molecular mechanisms of endotoxin activity - PubMed (original) (raw)

Review

Molecular mechanisms of endotoxin activity

J Schletter et al. Arch Microbiol. 1995 Dec.

Abstract

Endotoxin (lipopolysaccharide, LPS), a constituent of the outer membrane of the cell wall of gram-negative bacteria, exerts a wide variety of biological effects in humans. This review focuses on the molecular mechanisms underlying these activities and discusses structure-function relationships of the endotoxin molecule, its interaction with humoral and cellular receptors involved in cell activation, and transmembrane and intracellular signal transduction pathways.

PubMed Disclaimer

Similar articles

• Biochemistry and cell biology of bacterial endotoxins.
  Holst O, Ulmer AJ, Brade H, Flad HD, Rietschel ET. Holst O, et al. FEMS Immunol Med Microbiol. 1996 Dec 1;16(2):83-104. doi: 10.1111/j.1574-695X.1996.tb00126.x. FEMS Immunol Med Microbiol. 1996. PMID: 8988390 Review. No abstract available.
• Endotoxin in septic shock.
  Hoffman WD, Natanson C. Hoffman WD, et al. Anesth Analg. 1993 Sep;77(3):613-24. doi: 10.1213/00000539-199309000-00032. Anesth Analg. 1993. PMID: 8368563 Review. No abstract available.
• Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.
  Ingalls RR, Heine H, Lien E, Yoshimura A, Golenbock D. Ingalls RR, et al. Infect Dis Clin North Am. 1999 Jun;13(2):341-53, vii. doi: 10.1016/s0891-5520(05)70078-7. Infect Dis Clin North Am. 1999. PMID: 10340170 Review.
• Bacterial lipopolysaccharides: structure, metabolism and mechanisms of action.
  Freudenberg MA, Galanos C. Freudenberg MA, et al. Int Rev Immunol. 1990;6(4):207-21. doi: 10.3109/08830189009056632. Int Rev Immunol. 1990. PMID: 2102904 Review.
• Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion.
  Schromm AB, Brandenburg K, Loppnow H, Moran AP, Koch MH, Rietschel ET, Seydel U. Schromm AB, et al. Eur J Biochem. 2000 Apr;267(7):2008-13. doi: 10.1046/j.1432-1327.2000.01204.x. Eur J Biochem. 2000. PMID: 10727940

Cited by

• Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I.
  Ohto U, Yamakawa N, Akashi-Takamura S, Miyake K, Shimizu T. Ohto U, et al. J Biol Chem. 2012 Nov 23;287(48):40611-7. doi: 10.1074/jbc.M112.404608. Epub 2012 Oct 10. J Biol Chem. 2012. PMID: 23055527 Free PMC article.
• Recognition of Lipopolysaccharide and Activation of NF-κB by Cytosolic Sensor NOD1 in Teleost Fish.
  Bi D, Wang Y, Gao Y, Li X, Chu Q, Cui J, Xu T. Bi D, et al. Front Immunol. 2018 Jun 26;9:1413. doi: 10.3389/fimmu.2018.01413. eCollection 2018. Front Immunol. 2018. PMID: 30013548 Free PMC article.
• Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide.
  Elmanfi S, Sintim HO, Zhou J, Gürsoy M, Könönen E, Gürsoy UK. Elmanfi S, et al. Pathogens. 2020 Sep 26;9(10):792. doi: 10.3390/pathogens9100792. Pathogens. 2020. PMID: 32993127 Free PMC article.
• Computational Approaches to Toll-Like Receptor 4 Modulation.
  Billod JM, Lacetera A, Guzmán-Caldentey J, Martín-Santamaría S. Billod JM, et al. Molecules. 2016 Jul 30;21(8):994. doi: 10.3390/molecules21080994. Molecules. 2016. PMID: 27483231 Free PMC article. Review.
• Effects of deoxynivalenol and lipopolysaccharide on electrophysiological parameters in growing pigs.
  Halawa A, Dänicke S, Kersten S, Breves G. Halawa A, et al. Mycotoxin Res. 2012 Nov;28(4):243-52. doi: 10.1007/s12550-012-0135-x. Epub 2012 Jul 7. Mycotoxin Res. 2012. PMID: 23606196

References

1. 1. J Biol Chem. 1995 Apr 28;270(17):9904-10 - PubMed
2. 1. Science. 1994 Aug 5;265(5173):808-11 - PubMed
3. 1. J Immunol. 1989 May 1;142(9):3229-38 - PubMed
4. 1. J Biol Chem. 1995 Mar 10;270(10):5219-24 - PubMed
5. 1. Curr Top Microbiol Immunol. 1992;181:169-88 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Other Literature Sources

  • The Lens - Patent Citations Database