Predominance of normal karyotype in colorectal tumors from hereditary non-polyposis colorectal cancer patients - PubMed (original) (raw)

Comparative Study

Predominance of normal karyotype in colorectal tumors from hereditary non-polyposis colorectal cancer patients

M Muleris et al. Genes Chromosomes Cancer. 1995 Nov.

Abstract

We report the cytogenetic study of 9 colorectal tumors arising in patients with hereditary non-polyposis colorectal cancer (HNPCC). According to the cytogenetic classification of colorectal tumors previously proposed by us, 2 cases were of the trisomic type, 2 were of the monosomic type, and 5 had a normal karyotype. This represents a significant excess of tumors with normal karyotype in HNPCC tumors (56%) compared to sporadic cases (10/184 = 5%).

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