Expression of a type II collagen gene in the zebrafish embryonic axis - PubMed (original) (raw)
. 1995 Jul;203(3):363-76.
doi: 10.1002/aja.1002030308.
Affiliations
- PMID: 8589433
- DOI: 10.1002/aja.1002030308
Free article
Expression of a type II collagen gene in the zebrafish embryonic axis
Y L Yan et al. Dev Dyn. 1995 Jul.
Free article
Abstract
To understand the hierarchy of developmental controls underlying axis specification in vertebrate embryos, it is helpful to identify relationships between regulatory molecules and the genes that give axial cells their differentiated phenotypes. This work reports the cloning and expression pattern of one of these differentiation genes, a type II collagen (col2a1) gene from the zebrafish Danio rerio. Along the embryonic axis, col2a1 is expressed dynamically in three rows that are each a single cell wide: the notochord and the rows of cells immediately dorsal and ventral to it--the floor plate of the central nervous system, and the hypochord. In addition, col2a1 is expressed in the pharyngeal arches, the epithelium of the otic capsule, and in the mesenchyme of the neurocranium. Experiments probed the expression pattern of col2a1 relative to that of known or potential regulators of axis development, including axial, sonic hedgehog, twist, and cyclops. The results showed that the spatial and temporal pattern of col2a1 expression in axial mesoderm follows the expression of twist closer than other genes tested. In cyclops embryos, which lack an intact floor plate, col2a1 expression was usually low, but not missing in cells in the ventral spinal cord. Because col2a1 expression reveals abnormalities in the notochord of cyclopsb16 embryos, and less col2a1-expressing mesenchyme accumulates rostral to the notochord in cyclops embryos, the effects of the cyclopsb16 mutation are not confined to the central nervous system.
Similar articles
- Craniofacial cartilage morphogenesis requires zebrafish col11a1 activity.
Baas D, Malbouyres M, Haftek-Terreau Z, Le Guellec D, Ruggiero F. Baas D, et al. Matrix Biol. 2009 Oct;28(8):490-502. doi: 10.1016/j.matbio.2009.07.004. Epub 2009 Jul 26. Matrix Biol. 2009. PMID: 19638309 - Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways.
Odenthal J, van Eeden FJ, Haffter P, Ingham PW, Nüsslein-Volhard C. Odenthal J, et al. Dev Biol. 2000 Mar 15;219(2):350-63. doi: 10.1006/dbio.1999.9589. Dev Biol. 2000. PMID: 10694427 - Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in mutant zebrafish with axial signaling defects.
Glasgow E, Karavanov AA, Dawid IB. Glasgow E, et al. Dev Biol. 1997 Dec 15;192(2):405-19. doi: 10.1006/dbio.1997.8761. Dev Biol. 1997. PMID: 9441677 - [T-Box genes and developmental decisions that cells make].
Korzh VP. Korzh VP. Ontogenez. 2001 May-Jun;32(3):196-203. Ontogenez. 2001. PMID: 11548409 Review. Russian. - Tissue interactions during axial structure pattern formation in amphibia.
Malacinski GM, Youn BW, Jurand A. Malacinski GM, et al. Scan Electron Microsc. 1981;(Pt 2):307-18. Scan Electron Microsc. 1981. PMID: 7034171 Review.
Cited by
- Loss of collagen gene expression in the notochord of the tailless tunicate Molgula occulta.
Popsuj S, Di Gregorio A, Swalla BJ, Stolfi A. Popsuj S, et al. Integr Comp Biol. 2023 Dec 12;63(5):990-998. doi: 10.1093/icb/icad071. Integr Comp Biol. 2023. PMID: 37403333 Free PMC article. - PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in split hand/foot malformation.
Truong BT, Shull LC, Lencer E, Bend EG, Field M, Blue EE, Bamshad MJ, Skinner C, Everman D, Schwartz CE, Flanagan-Steet H, Artinger KB. Truong BT, et al. Dis Model Mech. 2023 Apr 1;16(4):dmm049977. doi: 10.1242/dmm.049977. Epub 2023 Apr 21. Dis Model Mech. 2023. PMID: 37083955 Free PMC article. - Rgp1 contributes to craniofacial cartilage development and Rab8a-mediated collagen II secretion.
Ritter DJ, Choudhary D, Unlu G, Knapik EW. Ritter DJ, et al. Front Endocrinol (Lausanne). 2023 Feb 9;14:1120420. doi: 10.3389/fendo.2023.1120420. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36843607 Free PMC article. - Genetically engineered zebrafish as models of skeletal development and regeneration.
Henke K, Farmer DT, Niu X, Kraus JM, Galloway JL, Youngstrom DW. Henke K, et al. Bone. 2023 Feb;167:116611. doi: 10.1016/j.bone.2022.116611. Epub 2022 Nov 14. Bone. 2023. PMID: 36395960 Free PMC article. Review. - Zebrafish models of alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye.
Yoon B, Yeung P, Santistevan N, Bluhm LE, Kawasaki K, Kueper J, Dubielzig R, VanOudenhove J, Cotney J, Liao EC, Grinblat Y. Yoon B, et al. Biol Open. 2022 May 15;11(5):bio059189. doi: 10.1242/bio.059189. Epub 2022 Jun 7. Biol Open. 2022. PMID: 35142342 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases