Immediate hypersensitivity in the Flinders rat: further evidence for a possible link between susceptibility to allergies and depression - PubMed (original) (raw)
Comparative Study
Immediate hypersensitivity in the Flinders rat: further evidence for a possible link between susceptibility to allergies and depression
V J Djurić et al. Brain Behav Immun. 1995 Sep.
Abstract
Rats of the Flinders sensitive line (FSL, selectively bred for their increased cholinergic activity and used as a genetic animal model of depression) were compared with their control counterparts, the Flinders resistant line, for their susceptibility to anaphylaxis and the response of small intestinal tissues to the muscarinic agonist, bethanechol. Following sensitization to ovalbumin (OA), rats of both lines were challenged in vivo either with 3 mg OA i.p. or with saline. In spite of the absence of line-related differences in IgE titers, FSL rats were more susceptible to the induction of anaphylactic shock as evidenced by (1) more pronounced mast cell degranulation; (2) a greater drop in rectal temperature; (3) higher hematocrit values; and (4) changes in gut function characterized by an elevation of basal short-circuit current and increased conductance (indicating increases in transport tone and permeability) of the tissues mounted in Ussing chambers. Thus, this study provides further evidence for a common cholinergic mechanisms in susceptibility to both allergies and depression.
Similar articles
- Strain-related difference in susceptibility to anaphylactic shock correlates with measures of spontaneous activity.
Djurić VJ, Kosecka U, Bienenstock J, Perdue MH. Djurić VJ, et al. Brain Behav Immun. 1994 Dec;8(4):355-70. doi: 10.1006/brbi.1994.1032. Brain Behav Immun. 1994. PMID: 7696719 - Naloxone exacerbates intestinal and systemic anaphylaxis in the rat.
Djurić VJ, Wang L, Bienenstock J, Perdue MH. Djurić VJ, et al. Brain Behav Immun. 1995 Jun;9(2):87-100. doi: 10.1006/brbi.1995.1010. Brain Behav Immun. 1995. PMID: 7549039 - In vitro airway responsiveness of Flinders sensitive and resistant line rats.
Janssen LJ, Djurić VJ, Wattie J, Otis J, O'Byrne PM. Janssen LJ, et al. Brain Behav Immun. 2000 Mar;14(1):62-7. doi: 10.1006/brbi.1999.0573. Brain Behav Immun. 2000. PMID: 10729218 - The Flinders Sensitive Line rat: a selectively bred putative animal model of depression.
Overstreet DH, Friedman E, Mathé AA, Yadid G. Overstreet DH, et al. Neurosci Biobehav Rev. 2005;29(4-5):739-59. doi: 10.1016/j.neubiorev.2005.03.015. Epub 2005 Apr 22. Neurosci Biobehav Rev. 2005. PMID: 15925699 Review. - Links between multiple chemical sensitivity and asthma in a rat model of cholinergic hypersensitivity: a brief review.
Overstreet DH, Djuric V. Overstreet DH, et al. Toxicol Ind Health. 1999 Aug;15(5):517-21. doi: 10.1177/074823379901500505. Toxicol Ind Health. 1999. PMID: 10487361 Review.
Cited by
- Influence of Stress and Depression on the Immune System in Patients Evaluated in an Anti-aging Unit.
Cañas-González B, Fernández-Nistal A, Ramírez JM, Martínez-Fernández V. Cañas-González B, et al. Front Psychol. 2020 Aug 4;11:1844. doi: 10.3389/fpsyg.2020.01844. eCollection 2020. Front Psychol. 2020. PMID: 32849086 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical