Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure - PubMed (original) (raw)

Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure

W A Paxton et al. Nat Med. 1996 Apr.

Abstract

Some individuals remain uninfected with human immunodeficiency virus type-1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocytes from nonexposed controls. Further studies indicated that their purified CD4+ lymphocytes were less susceptible to infection with multiple primary isolates of HIV-1 than were CD4+ lymphocytes from the nonexposed controls. This relative resistance to HIV-1 infection did not extend to T-cell line-adapted strains, was restricted by the envelope glycoprotein, was not explained by the cell surface density of CD4 molecules, but was associated with the activity of the C-C chemokines RANTES, MIP-1alpha, and MIP-1beta. This relative resistance of CD4+ lymphocytes may contribute to protection from HIV-1 in multiply exposed persons.

PubMed Disclaimer

Cited by

Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission.
Meddows-Taylor S, Donninger SL, Paximadis M, Schramm DB, Anthony FS, Gray GE, Kuhn L, Tiemessen CT. Meddows-Taylor S, et al. J Gen Virol. 2006 Jul;87(Pt 7):2055-2065. doi: 10.1099/vir.0.81709-0. J Gen Virol. 2006. PMID: 16760409 Free PMC article.
Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals.
Huang W, Toma J, Stawiski E, Fransen S, Wrin T, Parkin N, Whitcomb JM, Coakley E, Hecht FM, Deeks SG, Gandhi RT, Eshleman SH, Petropoulos CJ. Huang W, et al. AIDS Res Hum Retroviruses. 2009 Aug;25(8):795-802. doi: 10.1089/aid.2008.0252. AIDS Res Hum Retroviruses. 2009. PMID: 19678765 Free PMC article.
The mode and duration of anti-CD28 costimulation determine resistance to infection by macrophage-tropic strains of human immunodeficiency virus type 1 in vitro.
Creson JR, Lin AA, Li Q, Broad DF, Roberts MR, Anderson SJ. Creson JR, et al. J Virol. 1999 Nov;73(11):9337-47. doi: 10.1128/JVI.73.11.9337-9347.1999. J Virol. 1999. PMID: 10516042 Free PMC article.
The Association between CCL5/RANTES SNPs and Susceptibility to HIV-1 Infection: A Meta-Analysis.
Silva MJA, Marinho RL, Dos Santos PAS, Dos Santos CS, Ribeiro LR, Rodrigues YC, Lima KVB, Lima LNGC. Silva MJA, et al. Viruses. 2023 Sep 20;15(9):1958. doi: 10.3390/v15091958. Viruses. 2023. PMID: 37766364 Free PMC article. Review.
Genetic and Immunological Factors Involved in Natural Resistance to HIV-1 Infection.
Taborda-Vanegas N, Zapata W, Rugeles MT. Taborda-Vanegas N, et al. Open Virol J. 2011;5:35-43. doi: 10.2174/1874357901105010035. Epub 2011 May 11. Open Virol J. 2011. PMID: 21660188 Free PMC article.

Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure - PubMed (original) (raw)