Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis - PubMed (original) (raw)

Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis

G Stumm et al. Int J Cancer. 1996.

Abstract

Gene amplification or structural alteration of different erbB genes exerts a transforming effect in a variety of human neoplasms. Overexpression of the EGF receptor is associated with tumor initiation and progression of renal cell carcinoma (RCC). However, the role of erbB-2 in these processes remains unknown. We investigated 34 renal cell carcinomas for gene amplification and expression of the EGFR and erbB-2 genes at the mRNA and protein level and their relationship to pathological and clinical parameters. No amplification of both genes has been observed. However, high expression of the EGF receptor protein and p185erbB2 was frequent in RCC and statistically significantly related to higher tumor grades. We could demonstrate a close correlation of p185erbB2 overexpression with high EGF receptor levels. Co-overexpression of both receptor types was significantly associated with metastatic disease. Our results suggest a synergistic involvement of both EGF receptor and p185erbB2 in the progression of RCC.

PubMed Disclaimer

Cited by

ERBB2 is a potential diagnostic and prognostic biomarker in renal clear cell carcinoma.
Gao WN, Chen LG, Bao LR, He N, Hu TL, Lai C, Xu RF, Wang XF, Wang JY, Zhao JR, Meng Y. Gao WN, et al. Sci Rep. 2024 Oct 1;14(1):22775. doi: 10.1038/s41598-024-73574-7. Sci Rep. 2024. PMID: 39353993 Free PMC article.
Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment.
Zethoven M, Martelotto L, Pattison A, Bowen B, Balachander S, Flynn A, Rossello FJ, Hogg A, Miller JA, Frysak Z, Grimmond S, Fishbein L, Tischler AS, Gill AJ, Hicks RJ, Dahia PLM, Clifton-Bligh R, Pacak K, Tothill RW. Zethoven M, et al. Nat Commun. 2022 Oct 21;13(1):6262. doi: 10.1038/s41467-022-34011-3. Nat Commun. 2022. PMID: 36271074 Free PMC article.
The Role of ERBB Signaling Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma and Establishing a Prognostic Risk Assessment Model for Patients.
Wang Z, Li J, Zhang P, Zhao L, Huang B, Xu Y, Wu G, Xia Q. Wang Z, et al. Front Genet. 2022 Jul 12;13:862210. doi: 10.3389/fgene.2022.862210. eCollection 2022. Front Genet. 2022. PMID: 35903358 Free PMC article.
Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity.
Wu S, Ge Y, Lin K, Liu Q, Zhou H, Hu Q, Zhao Y, He W, Ju Z. Wu S, et al. Nucleic Acids Res. 2022 Apr 22;50(7):3764-3776. doi: 10.1093/nar/gkac179. Nucleic Acids Res. 2022. PMID: 35323972 Free PMC article.
Prognostic Impact of Membranous/Nuclear Epidermal Growth Factor Receptor Localization in Clear Cell Renal Cell Carcinoma.
Muroni MR, Ribback S, Sotgiu G, Kroeger N, Saderi L, Angius A, Cossu-Rocca P, De Miglio MR. Muroni MR, et al. Int J Mol Sci. 2021 Aug 14;22(16):8747. doi: 10.3390/ijms22168747. Int J Mol Sci. 2021. PMID: 34445451 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources
- Wiley
Other Literature Sources
- The Lens - Patent Citations
Medical
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis - PubMed (original) (raw)