An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes - PubMed (original) (raw)

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes

F Aniento et al. J Cell Biol. 1996 Apr.

Abstract

In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes. Both the association of beta COP to endosomal membranes as well as transport vesicle formation depend on the lumenal pH. We find that epsilon COP, but not gamma COP, is also associated to endosomes, and that this association is also lumenal pH dependent. Our data, thus, indicate that a subset of COPs is part of the mechanism regulating endosomal membrane transport, and that membrane association of these COPs is controlled by the acidic properties of early endosomes, presumably via a trans-membrane pH sensor.

PubMed Disclaimer

Cited by

Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein.
Bachert C, Lee TH, Linstedt AD. Bachert C, et al. Mol Biol Cell. 2001 Oct;12(10):3152-60. doi: 10.1091/mbc.12.10.3152. Mol Biol Cell. 2001. PMID: 11598199 Free PMC article.
Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.
Christensen EI, Devuyst O, Dom G, Nielsen R, Van der Smissen P, Verroust P, Leruth M, Guggino WB, Courtoy PJ. Christensen EI, et al. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8472-7. doi: 10.1073/pnas.1432873100. Epub 2003 Jun 18. Proc Natl Acad Sci U S A. 2003. PMID: 12815097 Free PMC article.
Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion.
Gekle M, Freudinger R, Mildenberger S. Gekle M, et al. J Physiol. 2001 Mar 15;531(Pt 3):619-29. doi: 10.1111/j.1469-7793.2001.0619h.x. J Physiol. 2001. PMID: 11251045 Free PMC article.
Engineering of ultraID, a compact and hyperactive enzyme for proximity-dependent biotinylation in living cells.
Kubitz L, Bitsch S, Zhao X, Schmitt K, Deweid L, Roehrig A, Barazzone EC, Valerius O, Kolmar H, Béthune J. Kubitz L, et al. Commun Biol. 2022 Jul 4;5(1):657. doi: 10.1038/s42003-022-03604-5. Commun Biol. 2022. PMID: 35788163 Free PMC article.
Retrograde transport from the pre-Golgi intermediate compartment and the Golgi complex is affected by the vacuolar H+-ATPase inhibitor bafilomycin A1.
Palokangas H, Ying M, Väänänen K, Saraste J. Palokangas H, et al. Mol Biol Cell. 1998 Dec;9(12):3561-78. doi: 10.1091/mbc.9.12.3561. Mol Biol Cell. 1998. PMID: 9843588 Free PMC article.

References

1. J Cell Biol. 1993 Dec;123(6 Pt 1):1373-87 - PubMed
1. J Cell Biol. 1995 Feb;128(4):549-61 - PubMed
1. Nature. 1992 Nov 26;360(6402):352-4 - PubMed
1. Annu Rev Cell Biol. 1993;9:129-61 - PubMed
1. Curr Opin Cell Biol. 1994 Aug;6(4):538-44 - PubMed

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes - PubMed (original) (raw)