Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis - PubMed (original) (raw)

Comparative Study

Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis

V Askanas et al. Ann Neurol. 1996 Mar.

Abstract

Paired-helical filaments (PHFs) are an important diagnostic criterion of the inclusion-body myositis (IBM) muscle biopsy; but, until now, their presence could be identified only by electronmicroscopy. In this report, we describe an easy immunocytochemical procedure, utilizing commercially available antibody, that enables reliable identification of muscle PHFs by light microscopy. This procedure greatly facilitates diagnosis of IBM.

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• SMI-31 immunoreactivity in inclusion body myositis.
  Spuler S, Engel AG. Spuler S, et al. Ann Neurol. 1997 Nov;42(5):815. doi: 10.1002/ana.410420521. Ann Neurol. 1997. PMID: 9392584 No abstract available.

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