Regulation of meiotic chromatin loop size by chromosomal position - PubMed (original) (raw)

Comparative Study

Regulation of meiotic chromatin loop size by chromosomal position

H H Heng et al. Proc Natl Acad Sci U S A. 1996.

Abstract

At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography. Similarly, chromatin loop lengths differ dramatically for interstitially and terminally located hamster telomeric sequences. Sequences, telomeric or otherwise, located at chromosome termini, closely associate with the meiotic proteinaceous core, forming shorter loops than identical interstitial sequences. Thus, we present evidence that different chromatin packaging mechanisms exist for interstitial versus terminal chromosomal regions, which act separately from those operating at the level of the DNA sequence. Chromosomal position plays the dominant role in chromatin packaging.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Chromosoma. 1973 Nov 21;44(2):231-53 - PubMed
    1. J Cell Sci. 1994 Oct;107 ( Pt 10):2749-60 - PubMed
    1. J Ultrastruct Res. 1981 May;75(2):131-41 - PubMed
    1. Exp Cell Res. 1983 Mar;144(1):63-72 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7690-4 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources