Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev - PubMed (original) (raw)
Comparative Study
Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev
R A Fridell et al. Proc Natl Acad Sci U S A. 1996.
Abstract
The human immunodeficiency virus type 1 (HIV-1) Rev protein is required for nuclear export of late HIV-1 mRNAs. This function is dependent on the mutationally defined Rev activation domain, which also forms a potent nuclear export signal. Transcription factor IIIA (TFIIIA) binds to 5S rRNA transcripts and this interaction has been proposed to play a role in the efficient nuclear export of 5S rRNA in amphibian oocytes. Here it is reported that amphibian TFIIIA proteins contain a sequence element with homology to the Rev activation domain that effectively substitutes for this domain in inducing the nuclear export of late HIV-1 mRNAs. It is further demonstrated that this TFIIIA sequence element functions as a protein nuclear export signal in both human cells and frog oocytes. Thus, this shared protein motif may play an analogous role in mediating the nuclear export of both late HIV-1 RNAs and 5S rRNA transcripts.
Similar articles
- Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.
Fridell RA, Bogerd HP, Cullen BR. Fridell RA, et al. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4421-4. doi: 10.1073/pnas.93.9.4421. Proc Natl Acad Sci U S A. 1996. PMID: 8633082 Free PMC article. - Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.
Fischer U, Pollard VW, Lührmann R, Teufel M, Michael MW, Dreyfuss G, Malim MH. Fischer U, et al. Nucleic Acids Res. 1999 Nov 1;27(21):4128-34. doi: 10.1093/nar/27.21.4128. Nucleic Acids Res. 1999. PMID: 10518602 Free PMC article. - A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals.
Henderson BR, Eleftheriou A. Henderson BR, et al. Exp Cell Res. 2000 Apr 10;256(1):213-24. doi: 10.1006/excr.2000.4825. Exp Cell Res. 2000. PMID: 10739668 - The ins and outs of HIV Rev.
Hope TJ. Hope TJ. Arch Biochem Biophys. 1999 May 15;365(2):186-91. doi: 10.1006/abbi.1999.1207. Arch Biochem Biophys. 1999. PMID: 10328811 Review. - The HIV-1 Rev protein.
Pollard VW, Malim MH. Pollard VW, et al. Annu Rev Microbiol. 1998;52:491-532. doi: 10.1146/annurev.micro.52.1.491. Annu Rev Microbiol. 1998. PMID: 9891806 Review.
Cited by
- Transcriptional factor III A promotes colorectal cancer progression by upregulating cystatin A.
Wang J, Tan Y, Jia QY, Tang FQ. Wang J, et al. World J Gastrointest Oncol. 2022 Oct 15;14(10):1918-1932. doi: 10.4251/wjgo.v14.i10.1918. World J Gastrointest Oncol. 2022. PMID: 36310710 Free PMC article. - Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.
Behrens RT, Aligeti M, Pocock GM, Higgins CA, Sherer NM. Behrens RT, et al. J Virol. 2017 Jan 18;91(3):e02107-16. doi: 10.1128/JVI.02107-16. Print 2017 Feb 1. J Virol. 2017. PMID: 27852860 Free PMC article. - NESdb: a database of NES-containing CRM1 cargoes.
Xu D, Grishin NV, Chook YM. Xu D, et al. Mol Biol Cell. 2012 Sep;23(18):3673-6. doi: 10.1091/mbc.E12-01-0045. Epub 2012 Jul 25. Mol Biol Cell. 2012. PMID: 22833564 Free PMC article. - Subcellular localization of V2 protein of Tomato leaf curl Java virus by using green fluorescent protein and yeast hybrid system.
Sharma P, Gaur RK, Ikegami M. Sharma P, et al. Protoplasma. 2011 Apr;248(2):281-8. doi: 10.1007/s00709-010-0166-0. Epub 2010 Jun 13. Protoplasma. 2011. PMID: 20549267 - The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection.
Eom CY, Heo WD, Craske ML, Meyer T, Lehman IR. Eom CY, et al. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4036-40. doi: 10.1073/pnas.0400738101. Epub 2004 Mar 9. Proc Natl Acad Sci U S A. 2004. PMID: 15010529 Free PMC article.
References
- Proc Natl Acad Sci U S A. 1979 Jan;76(1):241-5 - PubMed
- AIDS. 1995;9 Suppl A:S19-32 - PubMed
- Proc Natl Acad Sci U S A. 1980 Jul;77(7):4170-4 - PubMed
- Cell. 1984 Dec;39(3 Pt 2):479-89 - PubMed
- Nature. 1986 May 22-28;321(6068):412-7 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources