Integrin activation by R-ras - PubMed (original) (raw)
Integrin activation by R-ras
Z Zhang et al. Cell. 1996.
Free article
Abstract
Expression of a constitutively active R-ras converted two cell lines that grow in suspension into highly adherent cells. There was little change in cell surface expression of integrins, but attachment to surfaces coated with the integrin ligands was greatly enhanced. Cells transfected with activated R-ras bound integrin ligands from solution with higher affinities and assembled severalfold more fibronectin matrix than control transfectants. Introduction of a dominant negative R-ras into adherent cells reduced the adhesiveness of the cells, indicating that endogenous R-ras can control the ligand-binding activity of integrins. These results provide a mechanism for the modulation of integrin ligand-binding activity as well as novel function for R-ras.
Similar articles
- Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains.
Berrier AL, Mastrangelo AM, Downward J, Ginsberg M, LaFlamme SE. Berrier AL, et al. J Cell Biol. 2000 Dec 25;151(7):1549-60. doi: 10.1083/jcb.151.7.1549. J Cell Biol. 2000. PMID: 11134082 Free PMC article. - The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway.
Sethi T, Ginsberg MH, Downward J, Hughes PE. Sethi T, et al. Mol Biol Cell. 1999 Jun;10(6):1799-809. doi: 10.1091/mbc.10.6.1799. Mol Biol Cell. 1999. PMID: 10359597 Free PMC article. - The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.
Oertli B, Han J, Marte BM, Sethi T, Downward J, Ginsberg M, Hughes PE. Oertli B, et al. Oncogene. 2000 Oct 12;19(43):4961-9. doi: 10.1038/sj.onc.1203876. Oncogene. 2000. PMID: 11042683 - Integrins in cell adhesion and signaling.
Akiyama SK. Akiyama SK. Hum Cell. 1996 Sep;9(3):181-6. Hum Cell. 1996. PMID: 9183647 Review. - Integrin signaling and matrix assembly.
Ruoslahti E. Ruoslahti E. Tumour Biol. 1996;17(2):117-24. doi: 10.1159/000217975. Tumour Biol. 1996. PMID: 8658014 Review.
Cited by
- Normalization of tumor vasculature by R-Ras.
Sawada J, Komatsu M. Sawada J, et al. Cell Cycle. 2012 Dec 1;11(23):4285-6. doi: 10.4161/cc.22465. Epub 2012 Oct 24. Cell Cycle. 2012. PMID: 23095670 Free PMC article. No abstract available. - The ancestral type of the R-RAS protein has oncogenic potential.
Talajić A, Dominko K, Lončarić M, Ambriović-Ristov A, Ćetković H. Talajić A, et al. Cell Mol Biol Lett. 2024 Feb 21;29(1):27. doi: 10.1186/s11658-024-00546-0. Cell Mol Biol Lett. 2024. PMID: 38383288 Free PMC article. - A tale of three GTPases and a RIN in endothelial cell adhesion.
Fernandez-Borja M. Fernandez-Borja M. Cell Res. 2012 Oct;22(10):1426-8. doi: 10.1038/cr.2012.118. Epub 2012 Aug 14. Cell Res. 2012. PMID: 22890385 Free PMC article. - The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation.
Arora PD, He T, Ng K, McCulloch CA. Arora PD, et al. Mol Biol Cell. 2018 Oct 1;29(20):2481-2493. doi: 10.1091/mbc.E18-03-0147. Epub 2018 Aug 9. Mol Biol Cell. 2018. PMID: 30091651 Free PMC article. - R-Ras promotes metastasis of cervical cancer epithelial cells.
Mora N, Rosales R, Rosales C. Mora N, et al. Cancer Immunol Immunother. 2007 Apr;56(4):535-44. doi: 10.1007/s00262-006-0205-z. Epub 2006 Jul 22. Cancer Immunol Immunother. 2007. PMID: 16862428 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources