Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man - PubMed (original) (raw)
Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man
J Frahm et al. Magn Reson Med. 1996 Feb.
Abstract
Changes in glucose consumption, lactate production, and blood oxygenation were measured during prolonged neuronal activation (4-6 min) in human primary visual cortex using dynamic magnetic resonance spectroscopy and imaging. A decrease of steady-state glucose by 40% because of enhanced use by 21% was accompanied by a transient accumulation of lactate with a peak value of 170% 2.5 min after stimulation onset. Rapid blood hyperoxygenation indicating "uncoupling" of blood flow and oxidative metabolism was followed by a return to basal levels over 3 min. Thus, initial nonoxidative glucose consumption during functional activation is gradually complemented by a slower adjustment of oxidative phosphorylation that "recouples" perfusion and oxygen consumption at a new equilibrium.
Similar articles
- Dynamic NMR studies of perfusion and oxidative metabolism during focal brain activation.
Frahm J, Krueger G, Merboldt KD, Kleinschmidt A. Frahm J, et al. Adv Exp Med Biol. 1997;413:195-203. doi: 10.1007/978-1-4899-0056-2_21. Adv Exp Med Biol. 1997. PMID: 9238500 Clinical Trial. - Dynamic MRI sensitized to cerebral blood oxygenation and flow during sustained activation of human visual cortex.
Krüger G, Kleinschmidt A, Frahm J. Krüger G, et al. Magn Reson Med. 1996 Jun;35(6):797-800. doi: 10.1002/mrm.1910350602. Magn Reson Med. 1996. PMID: 8744004 - Decrease of glucose in the human visual cortex during photic stimulation.
Merboldt KD, Bruhn H, Hänicke W, Michaelis T, Frahm J. Merboldt KD, et al. Magn Reson Med. 1992 May;25(1):187-94. doi: 10.1002/mrm.1910250119. Magn Reson Med. 1992. PMID: 1593951 - What the clinician can learn from MRS lactate measurements.
Prichard JW. Prichard JW. NMR Biomed. 1991 Apr;4(2):99-102. doi: 10.1002/nbm.1940040212. NMR Biomed. 1991. PMID: 1859788 Review. - Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.
Magistretti PJ, Pellerin L. Magistretti PJ, et al. Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1155-63. doi: 10.1098/rstb.1999.0471. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10466143 Free PMC article. Review.
Cited by
- Functional activation of pyruvate dehydrogenase in human brain using hyperpolarized [1-13 C]pyruvate.
Zaidi M, Ma J, Thomas BP, Peña S, Harrison CE, Chen J, Lin SH, Derner KA, Baxter JD, Liticker J, Malloy CR, Bartnik-Olson B, Park JM. Zaidi M, et al. Magn Reson Med. 2024 May;91(5):1822-1833. doi: 10.1002/mrm.30015. Epub 2024 Jan 24. Magn Reson Med. 2024. PMID: 38265104 - A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments.
Theriault JE, Shaffer C, Dienel GA, Sander CY, Hooker JM, Dickerson BC, Barrett LF, Quigley KS. Theriault JE, et al. Neurosci Biobehav Rev. 2023 Oct;153:105373. doi: 10.1016/j.neubiorev.2023.105373. Epub 2023 Aug 25. Neurosci Biobehav Rev. 2023. PMID: 37634556 Free PMC article. Review. - Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics.
Koush Y, Rothman DL, Behar KL, de Graaf RA, Hyder F. Koush Y, et al. J Cereb Blood Flow Metab. 2022 Jun;42(6):911-934. doi: 10.1177/0271678X221076570. Epub 2022 Jan 26. J Cereb Blood Flow Metab. 2022. PMID: 35078383 Free PMC article. - Voluntary Behavior and Training Conditions Modulate in vivo Extracellular Glucose and Lactate in the Mouse Primary Motor Cortex.
Béland-Millar A, Messier C. Béland-Millar A, et al. Front Neurosci. 2022 Jan 4;15:732242. doi: 10.3389/fnins.2021.732242. eCollection 2021. Front Neurosci. 2022. PMID: 35058739 Free PMC article. - Simultaneous Measurement of the BOLD Effect and Metabolic Changes in Response to Visual Stimulation Using the MEGA-PRESS Sequence at 3 T.
Dwyer GE, Craven AR, Bereśniewicz J, Kazimierczak K, Ersland L, Hugdahl K, Grüner R. Dwyer GE, et al. Front Hum Neurosci. 2021 Mar 24;15:644079. doi: 10.3389/fnhum.2021.644079. eCollection 2021. Front Hum Neurosci. 2021. PMID: 33841118 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources