Cellular signaling pathways and cytoskeletal organization - PubMed (original) (raw)
Review
Cellular signaling pathways and cytoskeletal organization
K S Kosik et al. Ann N Y Acad Sci. 1996.
Abstract
We describe a possible mechanism by which the amyloid precursor protein (APP) may be linked to the intraneuronal pathology of Alzheimer's disease (AD). Extracellular proteolytic products of APP may directly or indirectly transduce signals to cells under normal as well as pathological conditions. This activity appears to reside in the cysteine-rich amino terminus of APP. How APP or its metabolic products may affect the phosphorylation of tau is considered.
Similar articles
- Secreted beta-APP stimulates MAP kinase and phosphorylation of tau in neurons.
Greenberg SM, Kosik KS. Greenberg SM, et al. Neurobiol Aging. 1995 May-Jun;16(3):403-7; discussion 407-8. doi: 10.1016/0197-4580(94)00172-w. Neurobiol Aging. 1995. PMID: 7566349 - Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.
España J, Giménez-Llort L, Valero J, Miñano A, Rábano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA. España J, et al. Biol Psychiatry. 2010 Mar 15;67(6):513-21. doi: 10.1016/j.biopsych.2009.06.015. Epub 2009 Aug 7. Biol Psychiatry. 2010. PMID: 19664757 - Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.
Ochalek A, Mihalik B, Avci HX, Chandrasekaran A, Téglási A, Bock I, Giudice ML, Táncos Z, Molnár K, László L, Nielsen JE, Holst B, Freude K, Hyttel P, Kobolák J, Dinnyés A. Ochalek A, et al. Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z. Alzheimers Res Ther. 2017. PMID: 29191219 Free PMC article. - Amyloid precursor protein and presenilin involvement in cell signaling.
Venezia V, Nizzari M, Carlo P, Corsaro A, Florio T, Russo C. Venezia V, et al. Neurodegener Dis. 2007;4(2-3):101-11. doi: 10.1159/000101834. Neurodegener Dis. 2007. PMID: 17596704 Review. - The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Zhu X, Lee HG, Raina AK, Perry G, Smith MA. Zhu X, et al. Neurosignals. 2002 Sep-Oct;11(5):270-81. doi: 10.1159/000067426. Neurosignals. 2002. PMID: 12566928 Review.
Cited by
- Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.
Wirths O, Multhaup G, Czech C, Feldmann N, Blanchard V, Tremp G, Beyreuther K, Pradier L, Bayer TA. Wirths O, et al. Brain Pathol. 2002 Jul;12(3):275-86. doi: 10.1111/j.1750-3639.2002.tb00442.x. Brain Pathol. 2002. PMID: 12146796 Free PMC article. - Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins.
Liou YC, Zhou XZ, Lu KP. Liou YC, et al. Trends Biochem Sci. 2011 Oct;36(10):501-14. doi: 10.1016/j.tibs.2011.07.001. Epub 2011 Aug 17. Trends Biochem Sci. 2011. PMID: 21852138 Free PMC article. Review. - Molecular mechanisms of neurodegeneration in Alzheimer's disease.
Crews L, Masliah E. Crews L, et al. Hum Mol Genet. 2010 Apr 15;19(R1):R12-20. doi: 10.1093/hmg/ddq160. Epub 2010 Apr 22. Hum Mol Genet. 2010. PMID: 20413653 Free PMC article. Review. - Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport.
Bayer TA, Wirths O, Majtényi K, Hartmann T, Multhaup G, Beyreuther K, Czech C. Bayer TA, et al. Brain Pathol. 2001 Jan;11(1):1-11. doi: 10.1111/j.1750-3639.2001.tb00376.x. Brain Pathol. 2001. PMID: 11145195 Free PMC article. Review. - Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
Dineley KT, Westerman M, Bui D, Bell K, Ashe KH, Sweatt JD. Dineley KT, et al. J Neurosci. 2001 Jun 15;21(12):4125-33. doi: 10.1523/JNEUROSCI.21-12-04125.2001. J Neurosci. 2001. PMID: 11404397 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources