Overweight, underweight, and mortality. A prospective study of 48,287 men and women - PubMed (original) (raw)
Overweight, underweight, and mortality. A prospective study of 48,287 men and women
J C Seidell et al. Arch Intern Med. 1996.
Abstract
Background: The relative contributions of a low and high body mass index (BMI [weight in kilograms divided by height in meters squared]) to all-cause and cause-specific mortality are still controversial.
Objective: To examine mortality rates in relation to BMI in a prospective cohort study of 48,287 Dutch men and women aged 30 to 54 years at baseline from 1974 to 1980.
Methods: During an average 12-year follow-up, 1319 deaths occurred. Relative risks (RRs) were calculated from the Cox proportional hazard model by using a BMI between 18.5 and 24.9 kg/m2 as the reference category.
Results: All-cause mortality was significantly increased in obese men (BMI, > or = 30 kg/m2; RR, 1.5; 95% confidence interval [CI], 1.1-2.0) and in underweight men (BMI, < 18.5 kg/m2; RR, 2.6; 95% CI, 1.8-3.9) but not in women. The increased risk in underweight men could be attributed to deaths within the first 5 years of follow-up and to lung cancer mortality among smokers. Coronary heart disease (CHD) mortality was about 3-fold higher among obese men and women. About 21% and 28% of CHD mortality in men and women, respectively, could be attributed to being overweight (BMI, > or = 25 kg/m2). The RR (but not the absolute risk) for CHD among obese men was still significant after adjustment for the presence of smoking, hypertension, hypercholesterolemia, and diabetes mellitus at baseline, and it was more pronounced for CHD among nonsmokers than among smokers (RR, 7.1; 95% CI, 2.3-21.7; and RR, 2.7; 95% CI, 1.5-4.7, respectively).
Conclusions: Total mortality was increased in obese and underweight men but not in women. The increased mortality in overweight men was mainly attributable to CHD and, in underweight men, to early mortality and especially lung cancer mortality among smokers.
Similar articles
- Underweight, overweight and obesity as risk factors for mortality and hospitalization.
Ringbäck Weitoft G, Eliasson M, Rosén M. Ringbäck Weitoft G, et al. Scand J Public Health. 2008 Mar;36(2):169-76. doi: 10.1177/1403494807085080. Scand J Public Health. 2008. PMID: 18519281 - [Body mass index and cancer incidence:a prospective cohort study in northern China].
Guo L, Li N, Wang G, Su K, Li F, Yang L, Ren J, Chang S, Chen S, Wu S, He J, Dai M. Guo L, et al. Zhonghua Liu Xing Bing Xue Za Zhi. 2014 Mar;35(3):231-6. Zhonghua Liu Xing Bing Xue Za Zhi. 2014. PMID: 24831616 Chinese. - Body-mass index and mortality in Korean men and women.
Jee SH, Sull JW, Park J, Lee SY, Ohrr H, Guallar E, Samet JM. Jee SH, et al. N Engl J Med. 2006 Aug 24;355(8):779-87. doi: 10.1056/NEJMoa054017. Epub 2006 Aug 22. N Engl J Med. 2006. PMID: 16926276 - Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta-Analysis and Systematic Review.
Zhu W, Wan R, Liu F, Hu J, Huang L, Li J, Hong K. Zhu W, et al. J Am Heart Assoc. 2016 Sep 9;5(9):e004006. doi: 10.1161/JAHA.116.004006. J Am Heart Assoc. 2016. PMID: 27613773 Free PMC article. Review. - Obesity and mortality: are the risks declining? Evidence from multiple prospective studies in the United States.
Mehta T, Fontaine KR, Keith SW, Bangalore SS, de los Campos G, Bartolucci A, Pajewski NM, Allison DB. Mehta T, et al. Obes Rev. 2014 Aug;15(8):619-29. doi: 10.1111/obr.12191. Epub 2014 Jun 9. Obes Rev. 2014. PMID: 24913899 Free PMC article. Review.
Cited by
- Effects of low body mass index and smoking on all-cause mortality among middle-aged and elderly Japanese.
Miyazaki M, Babazono A, Ishii T, Sugie T, Momose Y, Iwahashi M, Une H. Miyazaki M, et al. J Epidemiol. 2002 Jan;12(1):40-4. doi: 10.2188/jea.12.40. J Epidemiol. 2002. PMID: 11848183 Free PMC article. - Factors Associated with Body Mass Index(BMI) Among Older Adults: A Comparison Study of the U.S., Japan, and Korea.
Yeom J, Kim JK, Crimmins EM. Yeom J, et al. Hanguk Nonyonhak. 2009;29(4):1479-1500. Hanguk Nonyonhak. 2009. PMID: 25285028 Free PMC article. - Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue.
Meng X, Zou D, Shi Z, Duan Z, Mao Z. Meng X, et al. Lipids. 2004 Jan;39(1):37-41. doi: 10.1007/s11745-004-1199-1. Lipids. 2004. PMID: 15055233 - Body mass index and mortality in lung cancer patients: a systematic review and meta-analysis.
Wang J, Xu H, Zhou S, Wang D, Zhu L, Hou J, Tang J, Zhao J, Zhong S. Wang J, et al. Eur J Clin Nutr. 2018 Jan;72(1):4-17. doi: 10.1038/ejcn.2017.70. Epub 2017 May 17. Eur J Clin Nutr. 2018. PMID: 28513621 - The sex-specific association between BMI and coronary heart disease: a systematic review and meta-analysis of 95 cohorts with 1·2 million participants.
Mongraw-Chaffin ML, Peters SAE, Huxley RR, Woodward M. Mongraw-Chaffin ML, et al. Lancet Diabetes Endocrinol. 2015 Jun;3(6):437-449. doi: 10.1016/S2213-8587(15)00086-8. Epub 2015 May 7. Lancet Diabetes Endocrinol. 2015. PMID: 25960160 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources