Stat6 is required for mediating responses to IL-4 and for development of Th2 cells - PubMed (original) (raw)
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
M H Kaplan et al. Immunity. 1996 Mar.
Free article
Abstract
Interleukin-4 (IL-4) stimulation of cells leads to the activation of multiple signaling pathways, one of which involves Stat6. We have generated Stat6-deficient mice by gene targeting in embryonic stem cells to determine the role of this transcription factor in mediating the biologic functions of IL-4. IL-4-induced increases in the cell surface expression of both MHC class II antigens and IL-4 receptor are completely abrogated, and lymphocytes from Stat6-deficient animals fail to proliferate in response to IL-4. Stat6-deficient B cells do not produce IgE following in vivo immunization with anti-IgD. In addition, Stat6-deficient T lymphocytes fail to differentiate into Th2 cells in response to either IL-4 or Il-13. These results demonstrate that, despite the existence of multiple signaling pathways activated by IL-4, Stat6 is essential for mediating responses to IL-4 lymphocytes.
Similar articles
- Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells.
Bruns HA, Schindler U, Kaplan MH. Bruns HA, et al. J Immunol. 2003 Apr 1;170(7):3478-87. doi: 10.4049/jimmunol.170.7.3478. J Immunol. 2003. PMID: 12646608 - Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile.
Jankovic D, Kullberg MC, Noben-Trauth N, Caspar P, Paul WE, Sher A. Jankovic D, et al. J Immunol. 2000 Mar 15;164(6):3047-55. doi: 10.4049/jimmunol.164.6.3047. J Immunol. 2000. PMID: 10706693 - Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion.
Zhu J, Guo L, Watson CJ, Hu-Li J, Paul WE. Zhu J, et al. J Immunol. 2001 Jun 15;166(12):7276-81. doi: 10.4049/jimmunol.166.12.7276. J Immunol. 2001. PMID: 11390477 - Interleukin 4: signalling mechanisms and control of T cell differentiation.
Paul WE. Paul WE. Ciba Found Symp. 1997;204:208-16; discussion 216-9. doi: 10.1002/9780470515280.ch14. Ciba Found Symp. 1997. PMID: 9107423 Review. - The transcriptional regulator NFIL3 controls IgE production.
Rothman PB. Rothman PB. Trans Am Clin Climatol Assoc. 2010;121:156-71; discussion 171. Trans Am Clin Climatol Assoc. 2010. PMID: 20697558 Free PMC article. Review.
Cited by
- Differentiation and regulation of CD4+ T cell subsets in Parkinson's disease.
Sun X, Gu R, Bai J. Sun X, et al. Cell Mol Life Sci. 2024 Aug 17;81(1):352. doi: 10.1007/s00018-024-05402-0. Cell Mol Life Sci. 2024. PMID: 39153043 Free PMC article. Review. - Immunoglobulin class-switch recombination: Mechanism, regulation, and related diseases.
Liu JC, Zhang K, Zhang X, Guan F, Zeng H, Kubo M, Lee P, Candotti F, James LK, Camara NOS, Benlagha K, Lei JH, Forsman H, Yang L, Xiao W, Liu Z, Liu CH. Liu JC, et al. MedComm (2020). 2024 Aug 13;5(8):e662. doi: 10.1002/mco2.662. eCollection 2024 Aug. MedComm (2020). 2024. PMID: 39144468 Free PMC article. Review. - Activin A Promotes Differentiation of a Pathogenic Multicytokine IL-9-secreting CD4+ T Cell Population.
Ulrich BJ, Zhang W, Kenworthy BT, Kharwadkar R, Olson MR, Kaplan MH. Ulrich BJ, et al. J Immunol. 2024 Sep 15;213(6):823-830. doi: 10.4049/jimmunol.2300635. J Immunol. 2024. PMID: 39058312 - Whence and wherefore IgE?
Rahman RS, Wesemann DR. Rahman RS, et al. Immunol Rev. 2024 Sep;326(1):48-65. doi: 10.1111/imr.13373. Epub 2024 Jul 23. Immunol Rev. 2024. PMID: 39041740 Review. - Harnessing the innate immune system by revolutionizing macrophage-mediated cancer immunotherapy.
Reghu G, Vemula PK, Bhat SG, Narayanan S. Reghu G, et al. J Biosci. 2024;49:68 63. doi: 10.1007/s12038-024-00441-y. J Biosci. 2024. PMID: 38864238 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous