Mutations in the Wilms' tumor gene WT1 in leukemias - PubMed (original) (raw)

Case Reports

. 1996 Mar 15;87(6):2171-9.

Affiliations

• PMID: 8630376

Free article

Case Reports

Mutations in the Wilms' tumor gene WT1 in leukemias

L King-Underwood et al. Blood. 1996.

Free article

Abstract

The tissue-specific Wilms' tumor gene WT1 is expressed in a range of acute leukemias and hematopoietic cell lines. Using single-strand conformational polymorphism analysis, we have found mutations in the WT1 gene in 4 of 36 acute leukemias. WT1 mutations are found in 15% of cases of acute myeloid leukemia, in which they are associated with a poor response to chemotherapy. The mutations comprise small insertions in exons 1 and 7 and a nonsense mutation in exon 9. All are predicted to produce a truncated WT1 protein with absence or disruption of the zinc finger region. These are the first mutations in the WT1 gene to be described in sporadic leukemia.

PubMed Disclaimer

Similar articles

• Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias.
  Menssen HD, Renkl HJ, Rodeck U, Maurer J, Notter M, Schwartz S, Reinhardt R, Thiel E. Menssen HD, et al. Leukemia. 1995 Jun;9(6):1060-7. Leukemia. 1995. PMID: 7596170
• Mutation analysis of the WT1 gene in myelodysplastic syndromes.
  Hosoya N, Miyagawa K, Mitani K, Yazaki Y, Hirai H. Hosoya N, et al. Jpn J Cancer Res. 1998 Aug;89(8):821-4. doi: 10.1111/j.1349-7006.1998.tb00634.x. Jpn J Cancer Res. 1998. PMID: 9765617 Free PMC article.
• Effects of Denys-Drash syndrome point mutations on the DNA binding activity of the Wilms' tumor suppressor protein WT1.
  Borel F, Barilla KC, Hamilton TB, Iskandar M, Romaniuk PJ. Borel F, et al. Biochemistry. 1996 Sep 17;35(37):12070-6. doi: 10.1021/bi960758o. Biochemistry. 1996. PMID: 8810912
• The role of Wilms' tumor genes.
  Hirose M. Hirose M. J Med Invest. 1999 Aug;46(3-4):130-40. J Med Invest. 1999. PMID: 10687307 Review.
• [The Wilms' tumor suppressor gene WT1].
  Akiyama T. Akiyama T. Tanpakushitsu Kakusan Koso. 1997 Jul;42(10 Suppl):1612-7. Tanpakushitsu Kakusan Koso. 1997. PMID: 9279088 Review. Japanese. No abstract available.

Cited by

• EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
  Boulay G, Broye LC, Dong R, Iyer S, Sanalkumar R, Xing YH, Buisson R, Rengarajan S, Naigles B, Duc B, Volorio A, Awad ME, Renella R, Chebib I, Nielsen GP, Choy E, Cote GM, Zou L, Letovanec I, Stamenkovic I, Rivera MN, Riggi N. Boulay G, et al. Nat Commun. 2024 Aug 28;15(1):7460. doi: 10.1038/s41467-024-51851-3. Nat Commun. 2024. PMID: 39198430 Free PMC article.
• Dysregulated Expression of MiR-19b, MiR-25, MiR-17, WT1, and CEBPA in Patients with Acute Myeloid Leukemia and Association with Graft versus Host Disease after Hematopoietic Stem Cell Transplantation.
  Saadi MI, Tahmasebijaroubi F, Noshadi E, Rahimikian R, Karimi Z, Owjfard M, Niknam A, Abdolyousefi EN, Salek S, Tabrizi R, Jamali E. Saadi MI, et al. South Asian J Cancer. 2022 Apr 25;11(4):346-352. doi: 10.1055/s-0042-1742593. eCollection 2022 Oct. South Asian J Cancer. 2022. PMID: 36756106 Free PMC article.
• The Role of Wilms' Tumor Gene (WT1) Expression as a Marker of Minimal Residual Disease in Acute Myeloid Leukemia.
  Lazzarotto D, Candoni A. Lazzarotto D, et al. J Clin Med. 2022 Jun 9;11(12):3306. doi: 10.3390/jcm11123306. J Clin Med. 2022. PMID: 35743376 Free PMC article. Review.
• WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma.
  van Amerongen RA, Hagedoorn RS, Remst DFG, Assendelft DC, van der Steen DM, Wouters AK, van de Meent M, Kester MGD, de Ru AH, Griffioen M, van Veelen PA, Falkenburg JHF, Heemskerk MHM. van Amerongen RA, et al. J Immunother Cancer. 2022 Jun;10(6):e004409. doi: 10.1136/jitc-2021-004409. J Immunother Cancer. 2022. PMID: 35728869 Free PMC article.
• WT1 Gene Mutations, rs16754 Variant, and WT1 Overexpression as Prognostic Factors in Acute Myeloid Leukemia Patients.
  Koczkodaj D, Zmorzyński S, Grygalewicz B, Pieńkowska-Grela B, Styk W, Popek-Marciniec S, Filip AA. Koczkodaj D, et al. J Clin Med. 2022 Mar 28;11(7):1873. doi: 10.3390/jcm11071873. J Clin Med. 2022. PMID: 35407481 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Medical

  • MedlinePlus Health Information