HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV - PubMed (original) (raw)

Comparative Study

. 1996 Mar 1;271(5253):1291-3.

doi: 10.1126/science.271.5253.1291.

B Renjifo, M F McLane, R Marlink, C O'Hara, R Sutthent, C Wasi, P Vithayasai, V Vithayasai, C Apichartpiyakul, P Auewarakul, V Peña Cruz, D S Chui, R Osathanondh, K Mayer, T H Lee, M Essex

Affiliations

• PMID: 8638113
• DOI: 10.1126/science.271.5253.1291

Comparative Study

HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV

L E Soto-Ramirez et al. Science. 1996.

Abstract

Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV.

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Comment in

• Different subtypes of HIV-1 and cutaneous dendritic cells.
  Pope M, Ho DD, Moore JP, Weber J, Dittmar MT, Weiss RA. Pope M, et al. Science. 1997 Oct 31;278(5339):786-8. doi: 10.1126/science.278.5339.785c. Science. 1997. PMID: 9381184 No abstract available.

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