Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain - PubMed (original) (raw)
Review
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain
R B Darnell. Proc Natl Acad Sci U S A. 1996.
Abstract
Paraneoplastic neurologic disorders (PNDs) are believed to be autoimmune neuronal degenerations that develop in some patients with systemic cancer. A series of genes encoding previously undiscovered neuronal proteins have been cloned using antiserum from PND patients. Identification of these onconeural antigens suggests a reclassification of the disorders into four groups: those in which neuromuscular junction proteins, nerve terminal/vesicle-associated proteins, neuronal RNA binding proteins, or neuronal signal-transduction proteins serve as target antigens. This review considers insights into basic neurobiology, tumor immunology, and autoimmune neuronal degeneration offered by the characterization of the onconeural antigens.
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References
- Lancet. 1981 Aug 1;2(8240):224-6 - PubMed
- Nature. 1982 Jul 15;298(5871):240-4 - PubMed
- Nature. 1983 Jul 14-20;304(5922):129-35 - PubMed
- Neurology. 1984 Apr;34(4):480-5 - PubMed
- Proc Natl Acad Sci U S A. 1983 Dec;80(24):7636-40 - PubMed
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