A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1 - PubMed (original) (raw)
. 1996 Mar 18;220(2):280-4.
doi: 10.1006/bbrc.1996.0396.
Affiliations
- PMID: 8645296
- DOI: 10.1006/bbrc.1996.0396
A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1
Q B Tian et al. Biochem Biophys Res Commun. 1996.
Abstract
A new proteic killer gene system, hig, was identified on the plasmid Rts1. The hig locus consisting of a higA and higB is directly related to the temperature sensitive host cell growth conferred by Rts1. We proved that higB encoding presumably a 92-amino-acid polypeptide inhibited segregation of plasmid free cells, and higA encoding a 104-amino-acid polypeptide suppressed the higB function both in cis and in trans.
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