Inhibition of vagally mediated gastric acid secretion by activation of central prostanoid EP3 receptors in urethane-anaesthetized rats - PubMed (original) (raw)

Inhibition of vagally mediated gastric acid secretion by activation of central prostanoid EP3 receptors in urethane-anaesthetized rats

K Yokotani et al. Br J Pharmacol. 1996 Feb.

Abstract

1. We studied the effects of intracerebroventricular (i.c.v.) administration of prostanoid EP receptor ligands on vagally stimulated gastric acid secretion in rats anaesthetized with urethane. 2. Administration of misoprostol (EP3/EP2 receptor agonist) and sulprostone (EP3/EP1 receptor agonist) reduced vagally mediated gastric acid secretion in a dose-dependent manner (0.1, 0.3 and 1.0 nmol per animal). Butaprost (EP2 receptor agonist) (0.3 and 3.0 nmol per animal) was without effect. 17-Phenyl-omega- trinor PGE2 (EP1/EP3 receptor agonist) attenuated vagally mediated gastric acid secretion only at its highest dose (1.0 nmol per animal); this antisecretory effect was not prevented by pretreatment with SC-19220 (selective EP1 receptor antagonist) (20 nmol per animal, i.c.v.). 3. The potency of these test agents in attenuation of vagally mediated gastric acid secretion was as follows: misoprostol > or = sulprostone > > 17-phenyl-omega-trinor PGE2 > > > butaprost. These results suggest that activation of central prostanoid EP3 receptors induces inhibition of vagally mediated gastric acid secretion in rats.

PubMed Disclaimer

Similar articles

• Elevation of plasma noradrenaline levels in urethane-anaesthetized rats by activation of central prostanoid EP3 receptors.
  Yokotani K, Nishihara M, Murakami Y, Hasegawa T, Okuma Y, Osumi Y. Yokotani K, et al. Br J Pharmacol. 1995 Jun;115(4):672-6. doi: 10.1111/j.1476-5381.1995.tb14985.x. Br J Pharmacol. 1995. PMID: 7582489 Free PMC article.
• The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach.
  Araki H, Ukawa H, Sugawa Y, Yagi K, Suzuki K, Takeuchi K. Araki H, et al. Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:116-24. doi: 10.1046/j.1365-2036.2000.014s1116.x. Aliment Pharmacol Ther. 2000. PMID: 10807413
• Prostaglandin E receptor subtypes involved in stimulation of gastroduodenal bicarbonate secretion in rats and mice.
  Takeuchi K, Ukawa H, Furukawa O, Kawauchi S, Araki H, Sugimoto Y, Ishikawa A, Ushikubi F, Narumiya S. Takeuchi K, et al. J Physiol Pharmacol. 1999 Jun;50(2):155-67. J Physiol Pharmacol. 1999. PMID: 10424714
• Prostaglandin EP receptor subtypes involved in regulating HCO(3)(-) secretion from gastroduodenal mucosa.
  Takeuchi K, Koyama M, Hayashi S, Aihara E. Takeuchi K, et al. Curr Pharm Des. 2010;16(10):1241-51. doi: 10.2174/138161210790945931. Curr Pharm Des. 2010. PMID: 20166995 Review.
• Role of prostaglandin E receptor subtypes in gastroduodenal HCO3- secretion.
  Takeuchi K, Aihara E, Hayashi M, Sasaki Y. Takeuchi K, et al. Med Chem. 2005 Jul;1(4):395-403. doi: 10.2174/1573406054368657. Med Chem. 2005. PMID: 16789896 Review.

Cited by

• 16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors.
  Kunikata T, Tanaka A, Miyazawa T, Kato S, Takeuchi K. Kunikata T, et al. Dig Dis Sci. 2002 Apr;47(4):894-904. doi: 10.1023/a:1014725024519. Dig Dis Sci. 2002. PMID: 11991626
• Genetic deletion of the prostaglandin E2 E prostanoid receptor subtype 3 improves anatomical and functional outcomes after intracerebral hemorrhage.
  Leclerc JL, Lampert AS, Diller MA, Doré S. Leclerc JL, et al. Eur J Neurosci. 2015 May;41(10):1381-91. doi: 10.1111/ejn.12909. Eur J Neurosci. 2015. PMID: 25847406 Free PMC article.
• International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions.
  Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH. Norel X, et al. Pharmacol Rev. 2020 Oct;72(4):910-968. doi: 10.1124/pr.120.019331. Pharmacol Rev. 2020. PMID: 32962984 Free PMC article.
• Prostanoid EP(1)- and TP-receptors involved in the contraction of human pulmonary veins.
  Walch L, de Montpreville V, Brink C, Norel X. Walch L, et al. Br J Pharmacol. 2001 Dec;134(8):1671-8. doi: 10.1038/sj.bjp.0704423. Br J Pharmacol. 2001. PMID: 11739243 Free PMC article.

References

1. 1. Neuroscience. 1994 Oct;62(3):919-28 - PubMed
2. 1. Br J Pharmacol. 1991 Mar;102(3):573-6 - PubMed
3. 1. Arch Int Pharmacodyn Ther. 1969 Jul;180(1):46-56 - PubMed
4. 1. J Physiol. 1975 Dec;253(2):493-504 - PubMed
5. 1. Eur J Pharmacol. 1978 Dec 15;53(1):39-48 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Wiley

• Molecular Biology Databases

  • Guide to Pharmacology