Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations - PubMed (original) (raw)
. 1996 Jul 10;177(1):232-49.
doi: 10.1006/dbio.1996.0159.
Affiliations
- PMID: 8660891
- DOI: 10.1006/dbio.1996.0159
Free article
Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations
A M Boulet et al. Dev Biol. 1996.
Free article
Abstract
Mice carrying a nonfunctional allele of hoxc-4 have been generated by gene targeting. The phenotype of mice homozygous for this mutation is strikingly different from those reported in mice lacking the paralogous genes hoxa-4, hoxb-4, and hoxd-4. In contrast to the mutants of the paralogous family members, hoxc-4 homozygotes do not manifest abnormalities in the cervical vertebrae, but instead show vertebral defects that extend from the second thoracic vertebra (t2) to t11. Therefore, defects do not correspond to the anterior limit of expression of hoxc-4, but rather begin within the region of strong hoxc-4 expression in the prevertebral anlagen (i.e., pv7-14). While hoxc-4 mutant homozygotes that reach adulthood are fertile and appear outwardly normal, most die before weaning age. The high lethality appears to result from partial or complete blockage of the lumen of the esophagus over a large portion of its length, as well as disorganization of the esophageal musculature. Although the Drosophila homolog of hoxc-4, Deformed, is autoregulated, mutation of the hoxc-4 gene does not affect transcription of its paralogous family members. However, in hoxc-4 mutant embryos, transcription of both the hoxc-5 and hoxc-6 genes is altered. Employment of cissolidustrans analysis showed that the hoxc-4 mutation acts in cis to affect the pattern of hoxc-5 expression. Therefore, this mutation is likely to cause a reduction of hoxc-5 function as well as complete loss of hoxc-4 function.
Similar articles
- Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process.
Saegusa H, Takahashi N, Noguchi S, Suemori H. Saegusa H, et al. Dev Biol. 1996 Feb 25;174(1):55-64. doi: 10.1006/dbio.1996.0051. Dev Biol. 1996. PMID: 8626021 - Stage-specific homeotic vertebral transformations in mouse fetuses induced by maternal hyperthermia during somitogenesis.
Li ZL, Shiota K. Li ZL, et al. Dev Dyn. 1999 Dec;216(4-5):336-48. doi: 10.1002/(SICI)1097-0177(199912)216:4/5<336::AID-DVDY3>3.0.CO;2-5. Dev Dyn. 1999. PMID: 10633854 - Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: evidence for unique and redundant function.
Horan GS, Kovàcs EN, Behringer RR, Featherstone MS. Horan GS, et al. Dev Biol. 1995 May;169(1):359-72. doi: 10.1006/dbio.1995.1150. Dev Biol. 1995. PMID: 7750651 - Altering the spatial determinations in the mouse embryos by manipulating the Hox genes.
Tiret L, Le Mouellic H, Lallemand Y, Maury M, Brûlet P. Tiret L, et al. C R Acad Sci III. 1993 Sep;316(9):1009-24. C R Acad Sci III. 1993. PMID: 7915631 Review. English, French. - MHox and vertebrate skeletogenesis: the long and the short of it.
Brickell PM. Brickell PM. Bioessays. 1995 Sep;17(9):750-3. doi: 10.1002/bies.950170903. Bioessays. 1995. PMID: 8763826 Review.
Cited by
- Paralogous Genes Involved in Embryonic Development: Lessons from the Eye and Other Tissues.
Drobek M. Drobek M. Genes (Basel). 2022 Nov 9;13(11):2082. doi: 10.3390/genes13112082. Genes (Basel). 2022. PMID: 36360318 Free PMC article. Review. - Hox Proteins in the Regulation of Muscle Development.
Poliacikova G, Maurel-Zaffran C, Graba Y, Saurin AJ. Poliacikova G, et al. Front Cell Dev Biol. 2021 Oct 18;9:731996. doi: 10.3389/fcell.2021.731996. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34733846 Free PMC article. Review. - Cross-Species RNA-Seq Study Comparing Transcriptomes of Enriched Osteocyte Populations in the Tibia and Skull.
Wang N, Niger C, Li N, Richards GO, Skerry TM. Wang N, et al. Front Endocrinol (Lausanne). 2020 Sep 24;11:581002. doi: 10.3389/fendo.2020.581002. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33071985 Free PMC article. - Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.
Sato T, Kataoka K, Ito Y, Yokoyama S, Inui M, Mori M, Takahashi S, Akita K, Takada S, Ueno-Kudoh H, Asahara H. Sato T, et al. Elife. 2020 May 29;9:e53608. doi: 10.7554/eLife.53608. Elife. 2020. PMID: 32479258 Free PMC article. - Large intestine embryogenesis: Molecular pathways and related disorders (Review).
Kostouros A, Koliarakis I, Natsis K, Spandidos DA, Tsatsakis A, Tsiaoussis J. Kostouros A, et al. Int J Mol Med. 2020 Jul;46(1):27-57. doi: 10.3892/ijmm.2020.4583. Epub 2020 Apr 21. Int J Mol Med. 2020. PMID: 32319546 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous