A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis - PubMed (original) (raw)

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis

G Süss et al. J Exp Med. 1996.

Abstract

Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these same T cells. Murine splenic DC consist of both conventional CD8alpha- DC and a major population of CD8alpha+ DC. Whereas CD8- DC induce a vigorous proliferative response in CD4 T cells, CD8+ DC induce a lesser response that is associated with marked T cell apoptosis. By using various mixtures of T cells and DC from Fas-mutant lpr/lpr mice and Fas-ligand (FasL) mutant gld/gld mice, we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC. Furthermore, we show by direct surface staining that CD8+ DC, but not CD8- DC, express FasL at high levels. These findings indicate that FasL+ CD8+ DC are a specialized subgroup of DC with a role in the regulation of the response of primary peripheral T cells.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Exp Med. 1991 Mar 1;173(3):549-59 - PubMed
    1. J Exp Med. 1990 May 1;171(5):1753-71 - PubMed
    1. Nature. 1992 Mar 26;356(6367):314-7 - PubMed
    1. J Exp Med. 1992 Jul 1;176(1):47-58 - PubMed
    1. Semin Immunol. 1992 Aug;4(4):227-36 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources