Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins - PubMed (original) (raw)
Review
Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins
R L Beijersbergen et al. Biochim Biophys Acta. 1996.
Abstract
The retinoblastoma family of growth-inhibitory proteins act by binding and inhibiting several proteins with growth-stimulatory activity, the most prominent of which is the cellular transcription factor E2F. In higher organisms, progression through the cell division cycle is accompanied by the cyclical activation of a number of protein kinases, the cyclin-dependent kinases. Phosphorylation of retinoblastoma family proteins by these cyclin-dependent kinases leads to release of the associated growth-stimulatory proteins which in turn mediate progression through the cell division cycle.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources