DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila - PubMed (original) (raw)
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila
T Raabe et al. Cell. 1996.
Free article
Abstract
The specification of the R7 photoreceptor cell in the developing eye of Drosophila is dependent upon activation of the Sevenless (SEV) receptor tyrosine kinase. By screening for mutations that suppress signaling via a constitutively activated SEV protein, we have identified a novel gene, daughter of sevenless (dos). DOS is required not only for signal transduction via SEV but also in other receptor tyrosine kinase signaling pathways throughout development. The presence of an amino-terminally located pleckstrin homology domain and many potential tyrosine phosphorylation sites suggests that DOS functions as an adaptor protein able to interact with multiple signaling molecules. Our genetic analysis demonstrates that DOS functions upstream of Ras1 and defines a signaling pathway that is independent of direct binding of the DRK SH2/SH3 adaptor protein to the SEV receptor tyrosine kinase.
Similar articles
- SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.
Feller SM, Wecklein H, Lewitzky M, Kibler E, Raabe T. Feller SM, et al. Mech Dev. 2002 Aug;116(1-2):129-39. doi: 10.1016/s0925-4773(02)00147-8. Mech Dev. 2002. PMID: 12128212 - The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.
Allard JD, Chang HC, Herbst R, McNeill H, Simon MA. Allard JD, et al. Development. 1996 Apr;122(4):1137-46. doi: 10.1242/dev.122.4.1137. Development. 1996. PMID: 8620840 - In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling.
Bausenwein BS, Schmidt M, Mielke B, Raabe T. Bausenwein BS, et al. Mech Dev. 2000 Feb;90(2):205-15. doi: 10.1016/s0925-4773(99)00252-x. Mech Dev. 2000. PMID: 10640704 - Genetic analysis of the sevenless signal transduction pathway of Drosophila.
Hafen E, Dickson B, Raabe T, Brunner D, Oellers N, van der Straten A. Hafen E, et al. Dev Suppl. 1993:41-6. Dev Suppl. 1993. PMID: 8049486 Review. - Signaling mechanisms in induction of the R7 photoreceptor in the developing Drosophila retina.
Yamamoto D. Yamamoto D. Bioessays. 1994 Apr;16(4):237-44. doi: 10.1002/bies.950160406. Bioessays. 1994. PMID: 8031300 Review.
Cited by
- The Role of GAB1 in Cancer.
Pérez-Baena MJ, Cordero-Pérez FJ, Pérez-Losada J, Holgado-Madruga M. Pérez-Baena MJ, et al. Cancers (Basel). 2023 Aug 20;15(16):4179. doi: 10.3390/cancers15164179. Cancers (Basel). 2023. PMID: 37627207 Free PMC article. Review. - DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris.
Lu TY, Doherty J, Freeman MR. Lu TY, et al. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12544-9. doi: 10.1073/pnas.1403450111. Epub 2014 Aug 6. Proc Natl Acad Sci U S A. 2014. PMID: 25099352 Free PMC article. - Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.
Baril C, Lefrançois M, Sahmi M, Knævelsrud H, Therrien M. Baril C, et al. Genetics. 2014 Aug;197(4):1237-50. doi: 10.1534/genetics.114.166272. Epub 2014 Jun 3. Genetics. 2014. PMID: 24899161 Free PMC article. - A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila.
Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien M. Ashton-Beaucage D, et al. PLoS Biol. 2014 Mar 18;12(3):e1001809. doi: 10.1371/journal.pbio.1001809. eCollection 2014 Mar. PLoS Biol. 2014. PMID: 24643257 Free PMC article. - Receptor tyrosine kinases in Drosophila development.
Sopko R, Perrimon N. Sopko R, et al. Cold Spring Harb Perspect Biol. 2013 Jun 1;5(6):a009050. doi: 10.1101/cshperspect.a009050. Cold Spring Harb Perspect Biol. 2013. PMID: 23732470 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous