Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons - PubMed (original) (raw)

. 1996 Jul;122(7):2079-88.

doi: 10.1242/dev.122.7.2079.

Affiliations

• PMID: 8681789
• DOI: 10.1242/dev.122.7.2079

Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons

E Reissmann et al. Development. 1996 Jul.

Abstract

The neurotransmitter phenotype of sympathetic neurons is specified by interactions with the surrounding embryonic tissues. Adrenergic differentiation is elicited early during development in the vicinity of notochord and dorsal aorta and the importance of axial midline tissues for adrenergic differentiation has been well documented. We now provide evidence that bone morphogenetic proteins, BMP-4 and BMP-7 are signals produced by the dorsal aorta that direct sympathetic neuron differentiation. BMP-4 and BMP-7 are expressed in the dorsal aorta at critical times during sympathetic neuron differentiation and have the ability to enhance the formation of adrenergic sympathetic neurons both in cultures of neural crest cells and when ectopically expressed in the developing embryo.

PubMed Disclaimer

Similar articles

• Expression and regulation of type I BMP receptors during early avian sympathetic ganglion development.
  McPherson CE, Varley JE, Maxwell GD. McPherson CE, et al. Dev Biol. 2000 May 1;221(1):220-32. doi: 10.1006/dbio.2000.9684. Dev Biol. 2000. PMID: 10772803
• Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons.
  Schneider C, Wicht H, Enderich J, Wegner M, Rohrer H. Schneider C, et al. Neuron. 1999 Dec;24(4):861-70. doi: 10.1016/s0896-6273(00)81033-8. Neuron. 1999. PMID: 10624949
• Generation of neuroendocrine chromaffin cells from sympathoadrenal progenitors: beyond the glucocorticoid hypothesis.
  Huber K, Combs S, Ernsberger U, Kalcheim C, Unsicker K. Huber K, et al. Ann N Y Acad Sci. 2002 Oct;971:554-9. doi: 10.1111/j.1749-6632.2002.tb04526.x. Ann N Y Acad Sci. 2002. PMID: 12438182 Review.
• The development of the noradrenergic transmitter phenotype in postganglionic sympathetic neurons.
  Ernsberger U, Rohrer H. Ernsberger U, et al. Neurochem Res. 1996 Jul;21(7):823-9. doi: 10.1007/BF02532306. Neurochem Res. 1996. PMID: 8873087 Review.

Cited by

• Expansion of a neural crest gene signature following ectopic MYCN expression in sympathoadrenal lineage cells in vivo.
  Ibarra-García-Padilla R, Nambiar A, Hamre TA, Singleton EW, Uribe RA. Ibarra-García-Padilla R, et al. PLoS One. 2024 Sep 18;19(9):e0310727. doi: 10.1371/journal.pone.0310727. eCollection 2024. PLoS One. 2024. PMID: 39292691 Free PMC article.
• Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function.
  Ro YT, Jang BK, Shin CY, Park EU, Kim CG, Yang SI. Ro YT, et al. J Biomed Sci. 2010 Mar 17;17(1):18. doi: 10.1186/1423-0127-17-18. J Biomed Sci. 2010. PMID: 20233453 Free PMC article.
• The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system.
  Ernsberger U, Deller T, Rohrer H. Ernsberger U, et al. Cell Tissue Res. 2021 Dec;386(3):455-475. doi: 10.1007/s00441-021-03548-y. Epub 2021 Nov 10. Cell Tissue Res. 2021. PMID: 34757495 Free PMC article. Review.
• Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells.
  Stubbusch J, Narasimhan P, Huber K, Unsicker K, Rohrer H, Ernsberger U. Stubbusch J, et al. Neural Dev. 2013 Aug 20;8:16. doi: 10.1186/1749-8104-8-16. Neural Dev. 2013. PMID: 23961995 Free PMC article.
• Target-dependent inhibition of sympathetic neuron growth via modulation of a BMP signaling pathway.
  Moon JI, Birren SJ. Moon JI, et al. Dev Biol. 2008 Mar 15;315(2):404-17. doi: 10.1016/j.ydbio.2007.12.041. Epub 2008 Jan 8. Dev Biol. 2008. PMID: 18272145 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database