Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: a role for Fc receptor coligation - PubMed (original) (raw)
Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: a role for Fc receptor coligation
Y Yamashita et al. J Exp Med. 1996.
Abstract
Signals through the B cell antigen receptor lead to a variety of cellular events such as activation, anergy, and apoptosis. B cells select these outcomes to establish and maintain self-tolerance, and to mount adequate antibody responses. However, it is not fully understood how one and the same signal causes such different consequences. In the present study, we have studied the effect of activation signals on the outcome of responses to antigen receptor ligation. Two distinct growth-promoting signals were used to activate B cells. Ligation of either RP105, a newly discovered B cell surface molecule, or the CD40 molecule, drove B cells to proliferate. Resultant blastic cells were then exposed to anti-immunoglobulin M (IgM). Blast cells that had been stimulated with anti-RP105 ceased growing and underwent apoptosis after cross-linking of surface IgM. Coligation of the Fc gamma receptor IIB with surface IgM augmented, rather than aborted, this response. In contrast to RP105-activated B cells, blast cells that had been activated by CD40 ligation were unaltered by anti-IgM. On the other hand, CD40-activated B cells became extremely susceptible to Fas-mediated apoptosis, whereas RP105-activated B cells were much less sensitive. Anti-IgM-induced apoptosis in RP105 blasts was independent of Fas, because it was demonstrable with Fas-deficient MRL-lpr/lpr mice. These results demonstrate that the nature of an initial activation signal has a great influence on the fate of activated B cells after (re)engagement of the antigen receptor. RP105, as well as CD40, may be important in this life/death decision.
Similar articles
- Regulation of bcl-xL expression and Fas susceptibility in mouse B cells by CD40 ligation, surface IgM crosslinking and IL-4.
Koizumi T, Wang J, Suzuki Y, Masuda K, Watanabe T. Koizumi T, et al. Mol Immunol. 1996 Nov;33(16):1247-53. doi: 10.1016/s0161-5890(96)00084-3. Mol Immunol. 1996. PMID: 9129161 - Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis.
Jin H, Carrio R, Yu A, Malek TR. Jin H, et al. J Immunol. 2004 Jul 1;173(1):657-65. doi: 10.4049/jimmunol.173.1.657. J Immunol. 2004. PMID: 15210829 - [RP105 and B cell apoptosis].
Miura Y, Yamashita Y, Miyake K. Miura Y, et al. Nihon Rinsho. 1996 Jul;54(7):1784-9. Nihon Rinsho. 1996. PMID: 8741667 Review. Japanese. - B-cell receptor and Fas-mediated signals for life and death.
Carey GB, Donjerković D, Mueller CM, Liu S, Hinshaw JA, Tonnetti L, Davidson W, Scott DW. Carey GB, et al. Immunol Rev. 2000 Aug;176:105-15. doi: 10.1034/j.1600-065x.2000.00502.x. Immunol Rev. 2000. PMID: 11043771 Review.
Cited by
- Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells.
Fujita K, Kuwabara T, Wang B, Tanaka K, Ito K, Akishima-Fukasawa Y, Mikami T, Akasaka Y, Ishii T. Fujita K, et al. J Immunol Res. 2023 Oct 18;2023:9969079. doi: 10.1155/2023/9969079. eCollection 2023. J Immunol Res. 2023. PMID: 37886369 Free PMC article. - The role of CD180 in hematological malignancies and inflammatory disorders.
Edwards K, Lydyard PM, Kulikova N, Tsertsvadze T, Volpi EV, Chiorazzi N, Porakishvili N. Edwards K, et al. Mol Med. 2023 Jul 17;29(1):97. doi: 10.1186/s10020-023-00682-x. Mol Med. 2023. PMID: 37460961 Free PMC article. Review. - Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs.
Roe K, Shu GL, Draves KE, Giordano D, Pepper M, Clark EA. Roe K, et al. J Immunol. 2019 Oct 1;203(7):1715-1729. doi: 10.4049/jimmunol.1900549. Epub 2019 Sep 4. J Immunol. 2019. PMID: 31484732 Free PMC article. - CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.
Zhang Z, La Placa D, Nguyen T, Kujawski M, Le K, Li L, Shively JE. Zhang Z, et al. BMC Immunol. 2019 Jan 23;20(1):7. doi: 10.1186/s12865-019-0287-y. BMC Immunol. 2019. PMID: 30674283 Free PMC article. - CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus.
Yang Y, Wang C, Cheng P, Zhang X, Li X, Hu Y, Xu F, Hong F, Dong G, Xiong H. Yang Y, et al. Front Immunol. 2018 Nov 15;9:2643. doi: 10.3389/fimmu.2018.02643. eCollection 2018. Front Immunol. 2018. PMID: 30498494 Free PMC article.
References
- Annu Rev Immunol. 1992;10:489-518 - PubMed
- J Exp Med. 1996 Jan 1;183(1):77-85 - PubMed
- Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4048-52 - PubMed
- Annu Rev Immunol. 1994;12:457-86 - PubMed
- Annu Rev Immunol. 1994;12:881-922 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous