A novel function for Myc: inhibition of C/EBP-dependent gene activation - PubMed (original) (raw)
A novel function for Myc: inhibition of C/EBP-dependent gene activation
S Mink et al. Proc Natl Acad Sci U S A. 1996.
Abstract
We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present evidence that Myc downregulates these genes by inhibiting the function of C/EBP transcription factors. Detailed examination of the inhibitory mechanism shows that amino-terminal sequences of v-Myc, but not its DNA-binding domain, are required for the suppression of C/EBP-dependent transactivation. Our findings identify a new function for Myc and reveal a novel mechanism by which Myc affects the expression of other genes.
Similar articles
- Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.
Burk O, Mink S, Ringwald M, Klempnauer KH. Burk O, et al. EMBO J. 1993 May;12(5):2027-38. doi: 10.1002/j.1460-2075.1993.tb05852.x. EMBO J. 1993. PMID: 8491193 Free PMC article. - Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.
Ness SA, Kowenz-Leutz E, Casini T, Graf T, Leutz A. Ness SA, et al. Genes Dev. 1993 May;7(5):749-59. doi: 10.1101/gad.7.5.749. Genes Dev. 1993. PMID: 7684005 - Interaction of C/EBPbeta and v-Myb is required for synergistic activation of the mim-1 gene.
Mink S, Kerber U, Klempnauer KH. Mink S, et al. Mol Cell Biol. 1996 Apr;16(4):1316-25. doi: 10.1128/MCB.16.4.1316. Mol Cell Biol. 1996. PMID: 8657104 Free PMC article. - Function of the c-Myc oncoprotein in chromatin remodeling and transcription.
Amati B, Frank SR, Donjerkovic D, Taubert S. Amati B, et al. Biochim Biophys Acta. 2001 Mar 21;1471(3):M135-45. doi: 10.1016/s0304-419x(01)00020-8. Biochim Biophys Acta. 2001. PMID: 11250069 Review. - MYC protein interactors in gene transcription and cancer.
Lourenco C, Resetca D, Redel C, Lin P, MacDonald AS, Ciaccio R, Kenney TMG, Wei Y, Andrews DW, Sunnerhagen M, Arrowsmith CH, Raught B, Penn LZ. Lourenco C, et al. Nat Rev Cancer. 2021 Sep;21(9):579-591. doi: 10.1038/s41568-021-00367-9. Epub 2021 Jun 29. Nat Rev Cancer. 2021. PMID: 34188192 Review.
Cited by
- Single-molecule RNA-FISH analysis reveals stochasticity in reactivation of latent HIV-1 regulated by Nuclear Orphan Receptors NR4A and cMYC.
LaPorte A, Pathak R, Eliscovich C, Martins L, Nell R, Spivak A, Suzuki M, Planelles V, Singer R, Kalpana G. LaPorte A, et al. Res Sq [Preprint]. 2024 Apr 19:rs.3.rs-4166090. doi: 10.21203/rs.3.rs-4166090/v1. Res Sq. 2024. PMID: 38699331 Free PMC article. Preprint. - MYC dysfunction modulates stemness and tumorigenesis in breast cancer.
Liu Y, Zhu C, Tang L, Chen Q, Guan N, Xu K, Guan X. Liu Y, et al. Int J Biol Sci. 2021 Jan 1;17(1):178-187. doi: 10.7150/ijbs.51458. eCollection 2021. Int J Biol Sci. 2021. PMID: 33390842 Free PMC article. - ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia.
Namasu CY, Katzerke C, Bräuer-Hartmann D, Wurm AA, Gerloff D, Hartmann JU, Schwind S, Müller-Tidow C, Hilger N, Fricke S, Christopeit M, Niederwieser D, Behre G. Namasu CY, et al. Oncotarget. 2017 Oct 26;8(61):103626-103639. doi: 10.18632/oncotarget.22093. eCollection 2017 Nov 28. Oncotarget. 2017. PMID: 29262589 Free PMC article. - Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells.
Yu Z, Li T, Wang C, Deng S, Zhang B, Huo X, Zhang B, Wang X, Zhong Y, Ma X. Yu Z, et al. Oncotarget. 2016 Mar 29;7(13):15725-37. doi: 10.18632/oncotarget.7398. Oncotarget. 2016. PMID: 26894970 Free PMC article. - MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression.
Kim T, Cui R, Jeon YJ, Fadda P, Alder H, Croce CM. Kim T, et al. Oncotarget. 2015 Aug 7;6(22):18780-9. doi: 10.18632/oncotarget.3909. Oncotarget. 2015. PMID: 26003165 Free PMC article.
References
- Cell. 1977 May;11(1):95-103 - PubMed
- Oncogene. 1994 Dec;9(12):3635-45 - PubMed
- Genes Dev. 1995 Jan 15;9(2):168-81 - PubMed
- EMBO J. 1983;2(11):1969-75 - PubMed
- Mol Cell Biol. 1984 Dec;4(12):2587-93 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources