Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow transplantation for breast cancer - PubMed (original) (raw)
. 1996 Aug 15;88(4):1501-8.
Affiliations
- PMID: 8695872
Free article
Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow transplantation for breast cancer
B Eibl et al. Blood. 1996.
Free article
Abstract
Graft-versus-leukemia (GvL) has been shown to be an important immune-mediated antitumor effect in hematologic malignancies. It is still unknown whether such an immunemediated antitumor effect has clinical implications in patients with solid tumors. A 32-year-old woman with inflammatory breast cancer received a bone marrow transplant (BMT) from her HLA-identical sibling. During graft-versus-host disease (GvHD) cytotoxic T lymphocytes were grown and tested in a chromium-release assay against B and T lymphocytes of the patient and donor and against a panel of breast cancer cell lines. Resolution of liver metastases was observed simultaneously with clinical GvHD in the first weeks after transplant. In addition, minor histocompatibility antigen (MiHA)-specific and major histocompatibility complex (MHC) class I antigen-restricted cytotoxic T lymphocytes recognizing breast carcinoma target cells were isolated from the blood of the patient. Pretreatment of such target cells with tumor necrosis factor (TNF)-alpha but not with interferon (IFN)-alpha or IFN-gamma increased susceptibility of these cells to lysis by cytotoxic T lymphocytes. Clinical course and in vitro results suggest that a graft-versus-tumor (GvT) effect might exist after allogeneic BMT for breast cancer. However, clinical experience on a larger scale would be required to determine the clinical efficacy of GvT effects in patients with solid tumors.
Similar articles
- Correlation of minor histocompatibility antigen-specific cytotoxic T lymphocytes with graft-versus-host disease status and analyses of tissue distribution of their target antigens.
Niederwieser D, Grassegger A, Auböck J, Herold M, Nachbaur D, Rosenmayr A, Gächter A, Nussbaumer W, Gaggl S, Ritter M, et al. Niederwieser D, et al. Blood. 1993 Apr 15;81(8):2200-8. Blood. 1993. PMID: 8471780 - Strategies for the identification of T cell-recognized tumor antigens in hematological malignancies for improved graft-versus-tumor responses after allogeneic blood and marrow transplantation.
Zilberberg J, Feinman R, Korngold R. Zilberberg J, et al. Biol Blood Marrow Transplant. 2015 Jun;21(6):1000-7. doi: 10.1016/j.bbmt.2014.11.001. Epub 2014 Nov 20. Biol Blood Marrow Transplant. 2015. PMID: 25459643 Free PMC article. Review.
Cited by
- Graft-Versus-Solid-Tumor Effect: From Hematopoietic Stem Cell Transplantation to Adoptive Cell Therapies.
Barisic S, Childs RW. Barisic S, et al. Stem Cells. 2022 Jun 22;40(6):556-563. doi: 10.1093/stmcls/sxac021. Stem Cells. 2022. PMID: 35325242 Free PMC article. Review. - Improvement of abnormal cervical cytology possibly due to a graft-versus-tumor effect: A case report and literature review.
Hayashi N, Kato Y, Miyakawa H, Nakata T, Tamate K, Kikuchi T, Obata M. Hayashi N, et al. Clin Case Rep. 2021 Oct 4;9(10):e04835. doi: 10.1002/ccr3.4835. eCollection 2021 Oct. Clin Case Rep. 2021. PMID: 34631065 Free PMC article. - Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function.
Tymoszuk P, Nairz M, Brigo N, Petzer V, Heeke S, Kircher B, Hermann-Kleiter N, Klepsch V, Theurl I, Weiss G, Pfeifhofer-Obermair C. Tymoszuk P, et al. Front Oncol. 2020 Dec 4;10:584477. doi: 10.3389/fonc.2020.584477. eCollection 2020. Front Oncol. 2020. PMID: 33344239 Free PMC article. - Graft-versus-cancereffect and innovative approaches in thetreatment of refractory solid tumors.
Şahin U, Demirer T. Şahin U, et al. Turk J Med Sci. 2020 Nov 3;50(SI-2):1697-1706. doi: 10.3906/sag-1911-112. Turk J Med Sci. 2020. PMID: 32178508 Free PMC article. Review. - A Review of Allogeneic Hematopoietic Stem Cell Transplantation in Metastatic Breast Cancer.
Karadurmus N, Sahin U, Bahadir Basgoz B, Arpaci F, Demirer T. Karadurmus N, et al. Int J Hematol Oncol Stem Cell Res. 2018 Apr 1;12(2):111-116. Int J Hematol Oncol Stem Cell Res. 2018. PMID: 30233772 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials