Endotoxin signal transduction in macrophages - PubMed (original) (raw)
Review
Endotoxin signal transduction in macrophages
M J Sweet et al. J Leukoc Biol. 1996 Jul.
Abstract
Through its action on macrophages, bacterial lipopolysaccharide (LPS) or endotoxin can trigger responses that are protective or injurious to the host. This review examines the effects of LPS on macrophages by following events from the cell surface to the nucleus. The involvement of protein tyrosine kinases, mitogen-activated protein kinases, protein kinase C, G proteins, protein kinase A, ceramide-activated protein kinase, and microtubules in this process are reviewed. At the nuclear level, rel, C/EBP, Ets, Egr, fos, and jun family members have been implicated in activation of LPS-inducible gene expression.
Similar articles
- Fibroblast growth factor receptor signaling activates the human interstitial collagenase promoter via the bipartite Ets-AP1 element.
Newberry EP, Willis D, Latifi T, Boudreaux JM, Towler DA. Newberry EP, et al. Mol Endocrinol. 1997 Jul;11(8):1129-44. doi: 10.1210/mend.11.8.9958. Mol Endocrinol. 1997. PMID: 9212060 - c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.
Deng T, Karin M. Deng T, et al. Nature. 1994 Sep 8;371(6493):171-5. doi: 10.1038/371171a0. Nature. 1994. PMID: 8072547 - junB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2.
Coffer P, de Jonge M, Mettouchi A, Binetruy B, Ghysdael J, Kruijer W. Coffer P, et al. Oncogene. 1994 Mar;9(3):911-21. Oncogene. 1994. PMID: 8108135 - A common denominator linking glycogen metabolism, nuclear oncogenes and development.
Woodgett JR. Woodgett JR. Trends Biochem Sci. 1991 May;16(5):177-81. doi: 10.1016/0968-0004(91)90071-3. Trends Biochem Sci. 1991. PMID: 1652801 Review. - Transcriptional regulation by extracellular signals: mechanisms and specificity.
Hill CS, Treisman R. Hill CS, et al. Cell. 1995 Jan 27;80(2):199-211. doi: 10.1016/0092-8674(95)90403-4. Cell. 1995. PMID: 7834740 Review. No abstract available.
Cited by
- 15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome.
Kumar N, Gupta G, Anilkumar K, Fatima N, Karnati R, Reddy GV, Giri PV, Reddanna P. Kumar N, et al. Sci Rep. 2016 Aug 18;6:31649. doi: 10.1038/srep31649. Sci Rep. 2016. PMID: 27535180 Free PMC article. - Quercetin-3-_O_-_β_-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells.
Park JY, Lim MS, Kim SI, Lee HJ, Kim SS, Kwon YS, Chun W. Park JY, et al. Biomol Ther (Seoul). 2016 Nov 1;24(6):610-615. doi: 10.4062/biomolther.2016.026. Biomol Ther (Seoul). 2016. PMID: 27257013 Free PMC article. - Investigation on the Synergy between Membrane Permeabilizing Amphiphilic α-Hydrazido Acids and Commonly Used Antibiotics against Drug-Resistant Bacteria.
Minnelli C, Mangiaterra G, Laudadio E, Citterio B, Rinaldi S. Minnelli C, et al. Molecules. 2024 Aug 28;29(17):4078. doi: 10.3390/molecules29174078. Molecules. 2024. PMID: 39274926 Free PMC article. - Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells.
Tagoh H, Himes R, Clarke D, Leenen PJ, Riggs AD, Hume D, Bonifer C. Tagoh H, et al. Genes Dev. 2002 Jul 1;16(13):1721-37. doi: 10.1101/gad.222002. Genes Dev. 2002. PMID: 12101129 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous