Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition - PubMed (original) (raw)
Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition
C Kayalar et al. Proc Natl Acad Sci U S A. 1996.
Abstract
Three of the predominant features of apoptosis are internucleosomal DNA fragmentation, plasma membrane bleb formation, and retraction of cell processes. We demonstrate that actin is a substrate for the proapoptotic cysteine protease interleukin 1beta-converting enzyme. Actin cleaved by interleukin 1beta-converting enzyme can neither inhibit DNase I nor polymerize to its filamentous form as effectively as intact actin. These findings suggest a mechanism for the coordination of the proteolytic, endonucleolytic, and morphogenetic aspects of apoptosis.
Similar articles
- Resistance of actin to cleavage during apoptosis.
Song Q, Wei T, Lees-Miller S, Alnemri E, Watters D, Lavin MF. Song Q, et al. Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):157-62. doi: 10.1073/pnas.94.1.157. Proc Natl Acad Sci U S A. 1997. PMID: 8990178 Free PMC article. - Down-regulation of actin genes precedes microfilament network disruption and actin cleavage during p53-mediated apoptosis.
Guénal I, Risler Y, Mignotte B. Guénal I, et al. J Cell Sci. 1997 Feb;110 ( Pt 4):489-95. doi: 10.1242/jcs.110.4.489. J Cell Sci. 1997. PMID: 9067600 - Actin cleavage by CPP-32/apopain during the development of apoptosis.
Mashima T, Naito M, Noguchi K, Miller DK, Nicholson DW, Tsuruo T. Mashima T, et al. Oncogene. 1997 Mar 6;14(9):1007-12. doi: 10.1038/sj.onc.1200919. Oncogene. 1997. PMID: 9070648 - Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death.
Thornberry NA, Molineaux SM. Thornberry NA, et al. Protein Sci. 1995 Jan;4(1):3-12. doi: 10.1002/pro.5560040102. Protein Sci. 1995. PMID: 7773174 Free PMC article. Review. - Role of interleukin-1 beta converting enzyme (ICE) in leukemia.
Estrov Z, Talpaz M. Estrov Z, et al. Cytokines Mol Ther. 1996 Mar;2(1):1-11. Cytokines Mol Ther. 1996. PMID: 9384684 Review.
Cited by
- Changes of Ex Vivo Cervical Epithelial Cells Due to Electroporation with JMY.
Halász H, Szatmári Z, Kovács K, Koppán M, Papp S, Szabó-Meleg E, Szatmári D. Halász H, et al. Int J Mol Sci. 2023 Nov 28;24(23):16863. doi: 10.3390/ijms242316863. Int J Mol Sci. 2023. PMID: 38069185 Free PMC article. - Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factors.
Campellone KG, Lebek NM, King VL. Campellone KG, et al. Eur J Cell Biol. 2023 Jun;102(2):151301. doi: 10.1016/j.ejcb.2023.151301. Epub 2023 Mar 2. Eur J Cell Biol. 2023. PMID: 36907023 Free PMC article. - Amoebal Tubulin Cleavage Late during Infection Is a Characteristic Feature of Mimivirus but Not of Marseillevirus.
Goyal N, Barai A, Sen S, Kondabagil K. Goyal N, et al. Microbiol Spectr. 2022 Dec 21;10(6):e0275322. doi: 10.1128/spectrum.02753-22. Epub 2022 Dec 1. Microbiol Spectr. 2022. PMID: 36453900 Free PMC article. - Regulation of Mitochondrial Function by the Actin Cytoskeleton.
Illescas M, Peñas A, Arenas J, Martín MA, Ugalde C. Illescas M, et al. Front Cell Dev Biol. 2021 Dec 21;9:795838. doi: 10.3389/fcell.2021.795838. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34993202 Free PMC article. Review. - The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis.
King VL, Leclair NK, Coulter AM, Campellone KG. King VL, et al. PLoS Genet. 2021 Apr 19;17(4):e1009512. doi: 10.1371/journal.pgen.1009512. eCollection 2021 Apr. PLoS Genet. 2021. PMID: 33872315 Free PMC article.
References
- Cell. 1993 Nov 19;75(4):641-52 - PubMed
- Cell Death Differ. 1994 Jul;1(1):7-9 - PubMed
- Proc Natl Acad Sci U S A. 1993 May 15;90(10):4533-7 - PubMed
- Nucleic Acids Res. 1993 Sep 11;21(18):4206-9 - PubMed
- Science. 1994 Feb 11;263(5148):826-8 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources