Psychogenic stress induces chromosomal and DNA damage - PubMed (original) (raw)
Psychogenic stress induces chromosomal and DNA damage
H K Fischman et al. Int J Neurosci. 1996 Feb.
Abstract
In this investigation, rats subjected to swim stress showed within 24 hours significant increases in both the level of chromosome aberrations and Sister Chromatid Exchanges (SCEs) in bone marrow cells. The generality of cytogenetic damage by behavioral stressors was demonstrated by exposing rats to both cold-and warm-water forced swims, to white noise, and to continuous or intermittent inescapable foot shock stress (IFS). The induction of chromosome aberrations and SCEs, to differing degrees, by stressors that differ both quantitatively and qualitatively, demonstrates that this is a general phenomenon of stress. The use of an additional measure, unscheduled DNA Synthesis (UDS) showed that stress-induced genotoxic damage can occur in a second cell type and on a molecular as well as chromosomal level. These results indicate that there may be a cellular genetic basis for some of the effects of stress.
Similar articles
- Sister chromatid exchanges induced by behavioral stress.
Fischman HK, Kelly DD. Fischman HK, et al. Ann N Y Acad Sci. 1987;496:426-35. doi: 10.1111/j.1749-6632.1987.tb35798.x. Ann N Y Acad Sci. 1987. PMID: 3474982 - Chromosomes and stress.
Fischman HK, Kelly DD. Fischman HK, et al. Int J Neurosci. 1999 Aug;99(1-4):201-19. doi: 10.3109/00207459908994325. Int J Neurosci. 1999. PMID: 10495217 - In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol.
Siddique YH, Afzal M. Siddique YH, et al. Indian J Exp Biol. 2005 Mar;43(3):291-3. Indian J Exp Biol. 2005. PMID: 15816420 - DNA damage processing and aberration formation in plants.
Schubert I, Pecinka A, Meister A, Schubert V, Klatte M, Jovtchev G. Schubert I, et al. Cytogenet Genome Res. 2004;104(1-4):104-8. doi: 10.1159/000077473. Cytogenet Genome Res. 2004. PMID: 15162022 Review.
Cited by
- Perception matters: Stressful life events increase breast cancer risk.
Fischer A, Ziogas A, Anton-Culver H. Fischer A, et al. J Psychosom Res. 2018 Jul;110:46-53. doi: 10.1016/j.jpsychores.2018.03.010. Epub 2018 Mar 26. J Psychosom Res. 2018. PMID: 29764605 Free PMC article. - Factors influencing behavior in the forced swim test.
Bogdanova OV, Kanekar S, D'Anci KE, Renshaw PF. Bogdanova OV, et al. Physiol Behav. 2013 Jun 13;118:227-39. doi: 10.1016/j.physbeh.2013.05.012. Epub 2013 May 14. Physiol Behav. 2013. PMID: 23685235 Free PMC article. Review. - The influence of bio-behavioural factors on tumour biology: pathways and mechanisms.
Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, Stefanek M, Sood AK. Antoni MH, et al. Nat Rev Cancer. 2006 Mar;6(3):240-8. doi: 10.1038/nrc1820. Nat Rev Cancer. 2006. PMID: 16498446 Free PMC article. Review. - Mitigating the risk of radiation-induced cancers: limitations and paradigms in drug development.
Yoo SS, Jorgensen TJ, Kennedy AR, Boice JD Jr, Shapiro A, Hu TC, Moyer BR, Grace MB, Kelloff GJ, Fenech M, Prasanna PG, Coleman CN. Yoo SS, et al. J Radiol Prot. 2014 Jun;34(2):R25-52. doi: 10.1088/0952-4746/34/2/R25. Epub 2014 Apr 14. J Radiol Prot. 2014. PMID: 24727460 Free PMC article. Review. - Negative Valence Life Events Promote Breast Cancer Development.
Fischer A, Ziogas A, Anton-Culver H. Fischer A, et al. Clin Breast Cancer. 2018 Aug;18(4):e521-e528. doi: 10.1016/j.clbc.2017.10.017. Epub 2017 Nov 1. Clin Breast Cancer. 2018. PMID: 29170032 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical