Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs - PubMed (original) (raw)
Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs
C L Martel et al. Neurosci Lett. 1996.
Free article
Abstract
An intracarotid brain infusion/capillary depletion technique was used in guinea pigs to examine cerebral capillary sequestration and transport into brain parenchyma of sA beta 1-40 and sA beta 1-42, synthetic peptides identical to two forms of the amyloid beta peptide found in Alzheimer's disease lesions: the 40 residue form, found primarily in vascular deposits, and the 42 residue form, found primarily in senile plaques. The peptides crossed well into the brain parenchyma via a specific transport mechanism for which sA beta 1-40 had an approximately two-fold greater affinity than sA beta 1-42. There was significant capillary sequestration of sA beta 1-40, but retention by the microvasculature of sA beta 1-42 was negligible. These data suggest that the level of the 40 residue peptide in cerebral vasculature and of the 42 residue peptide in parenchyma could be regulated by blood-brain barrier sequestration and transport of their respective circulating precursors.
Similar articles
- Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta.
Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W, McComb JG, Frangione B, Ghiso J, Zlokovic BV. Martel CL, et al. J Neurochem. 1997 Nov;69(5):1995-2004. doi: 10.1046/j.1471-4159.1997.69051995.x. J Neurochem. 1997. PMID: 9349544 - Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy.
Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Mackic JB, et al. J Neurochem. 1998 Jan;70(1):210-5. doi: 10.1046/j.1471-4159.1998.70010210.x. J Neurochem. 1998. PMID: 9422364 - Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.
Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. Mackic JB, et al. Vascul Pharmacol. 2002 Jun;38(6):303-13. doi: 10.1016/s1537-1891(02)00198-2. Vascul Pharmacol. 2002. PMID: 12529925 - [Cholesterol and Alzheimer's disease].
Kálmán J, Janka Z. Kálmán J, et al. Orv Hetil. 2005 Sep 11;146(37):1903-11. Orv Hetil. 2005. PMID: 16255374 Review. Hungarian.
Cited by
- Molecular Profiles of Amyloid-β Proteoforms in Typical and Rapidly Progressive Alzheimer's Disease.
Noor A, Zafar S, Shafiq M, Younas N, Siegert A, Mann FA, Kruss S, Schmitz M, Dihazi H, Ferrer I, Zerr I. Noor A, et al. Mol Neurobiol. 2022 Jan;59(1):17-34. doi: 10.1007/s12035-021-02566-9. Epub 2021 Oct 7. Mol Neurobiol. 2022. PMID: 34618331 Free PMC article. - Neurodegenerative Proteinopathies in the Proteoform Spectrum-Tools and Challenges.
Noor A, Zafar S, Zerr I. Noor A, et al. Int J Mol Sci. 2021 Jan 22;22(3):1085. doi: 10.3390/ijms22031085. Int J Mol Sci. 2021. PMID: 33499319 Free PMC article. Review. - Computational Study of Natural Compounds for the Clearance of Amyloid-Βeta: A Potential Therapeutic Management Strategy for Alzheimer's Disease.
Ahmad SS, Khan H, Danish Rizvi SM, Ansari SA, Ullah R, Rastrelli L, Mahmood HM, Siddiqui MH. Ahmad SS, et al. Molecules. 2019 Sep 5;24(18):3233. doi: 10.3390/molecules24183233. Molecules. 2019. PMID: 31491967 Free PMC article. - The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice.
Stanley M, Macauley SL, Caesar EE, Koscal LJ, Moritz W, Robinson GO, Roh J, Keyser J, Jiang H, Holtzman DM. Stanley M, et al. J Neurosci. 2016 Nov 16;36(46):11704-11715. doi: 10.1523/JNEUROSCI.2119-16.2016. J Neurosci. 2016. PMID: 27852778 Free PMC article. - Alzheimer's Disease: Mechanism and Approach to Cell Therapy.
Amemori T, Jendelova P, Ruzicka J, Urdzikova LM, Sykova E. Amemori T, et al. Int J Mol Sci. 2015 Nov 4;16(11):26417-51. doi: 10.3390/ijms161125961. Int J Mol Sci. 2015. PMID: 26556341 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical