Hepatocyte growth factor and acute phase proteins in patients with chronic liver diseases - PubMed (original) (raw)
Affiliations
- PMID: 8721905
Hepatocyte growth factor and acute phase proteins in patients with chronic liver diseases
G Shiota et al. J Med. 1995.
Abstract
Serum hepatocyte growth factor (HGF) levels are increased in patients with liver diseases. HGF has been recently reported to stimulate production of acute phase proteins such as alpha 2-macroglobulin and albumin of hepatocytes in primary culture. To clarify whether serum HGF concentrations have any relation to concentrations of acute phase proteins, we measured serum HGF and acute phase proteins in chronic liver diseases where the synthesis of many plasma proteins is decreased with the decline of liver function. Eighty three patients with chronic liver diseases and 20 normal individuals were examined for serum HGF, albumin, C-reactive protein (CRP), alpha-fetoprotein (AFP), alpha 1-acid glycoprotein (alpha 1-AG) and alpha 2-macroglobulin (alpha 2-MG). Mean values for serum HGF in chronic hepatitis (CH), liver cirrhosis (LC) and hepatocellular carcinoma (HCC) were 0.37, 0.79 and 0.66 ng/mL, which were significantly higher than those in controls (p < 0.05, p < 0.0001 and p < 0.0001, respectively). The levels of CRP increased in parallel with the progression of chronic liver diseases. Levels of alpha 2-MG were not changed in patients with CH Or LC, while those in patients with HCC were significantly higher than in controls or LC (p < 0.01 and p < 0.05, respectively). Serum HGF showed a positive correlation with CRP and a negative correlation with albumin. However, no relations between HGF and alpha 2-MG were observed. These data suggest that serum levels of acute phase proteins such as albumin and alpha 2-MG are more closely associated with the degree of hepatic dysfunction than serum HGF levels.
Similar articles
- Serum hepatocyte growth factor levels in liver diseases: clinical implications.
Shiota G, Okano J, Kawasaki H, Kawamoto T, Nakamura T. Shiota G, et al. Hepatology. 1995 Jan;21(1):106-12. Hepatology. 1995. PMID: 7806142 - Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C-viral chronic liver diseases.
Yamagamim H, Moriyama M, Matsumura H, Aoki H, Shimizu T, Saito T, Kaneko M, Shioda A, Tanaka N, Arakawa Y. Yamagamim H, et al. Cancer. 2002 Aug 15;95(4):824-34. doi: 10.1002/cncr.10732. Cancer. 2002. PMID: 12209727 - Association between serum hepatocyte growth factor and survival in untreated hepatocellular carcinoma.
Vejchapipat P, Tangkijvanich P, Theamboonlers A, Chongsrisawat V, Chittmittrapap S, Poovorawan Y. Vejchapipat P, et al. J Gastroenterol. 2004 Dec;39(12):1182-8. doi: 10.1007/s00535-004-1469-8. J Gastroenterol. 2004. PMID: 15622483 - Hepatic diseases in the elderly.
Van Dam J, Zeldis JB. Van Dam J, et al. Gastroenterol Clin North Am. 1990 Jun;19(2):459-72. Gastroenterol Clin North Am. 1990. PMID: 2163984 Review. - [The role of acute phase proteins in the pathogenesis of chronic periapical granuloma].
Márton I, Kiss C, Szabó T. Márton I, et al. Fogorv Sz. 1990 Aug;83(8):235-9. Fogorv Sz. 1990. PMID: 1698164 Review. Hungarian.
Cited by
- Serum Hepatocyte Growth Factor Concentration Correlates with Albuminuria in Individuals with Optimal Blood Pressure and Untreated Arterial Hypertension.
Fistrek Prlic M, Vukovic Brinar I, Kos J, Dika Z, Ivandic E, Fucek M, Jelakovic B. Fistrek Prlic M, et al. Biomedicines. 2024 Sep 30;12(10):2233. doi: 10.3390/biomedicines12102233. Biomedicines. 2024. PMID: 39457546 Free PMC article. - C-Reactive Protein to Albumin Ratio Predicts 30-Day and 1-Year Mortality in Postoperative Patients after Admission to the Intensive Care Unit.
Oh TK, Ji E, Na HS, Min B, Jeon YT, Do SH, Song IA, Park HP, Hwang JW. Oh TK, et al. J Clin Med. 2018 Feb 26;7(3):39. doi: 10.3390/jcm7030039. J Clin Med. 2018. PMID: 29495423 Free PMC article. - A preliminary study of inflammatory markers in non-alcoholic steatohepatitis patients.
Priya MT, Sheriff DS. Priya MT, et al. Libyan J Med. 2010 Mar 19;5. doi: 10.3402/ljm.v5i0.5071. Libyan J Med. 2010. PMID: 21483580 Free PMC article. - Reference distributions for the negative acute-phase proteins, albumin, transferrin, and transthyretin: a comparison of a large cohort to the world's literature.
Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O. Ritchie RF, et al. J Clin Lab Anal. 1999;13(6):280-6. doi: 10.1002/(SICI)1098-2825(1999)13:6<280::AID-JCLA5>3.0.CO;2-U. J Clin Lab Anal. 1999. PMID: 10633295 Free PMC article. - Reference distributions for alpha2-macroglobulin: a comparison of a large cohort to the world's literature.
Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O. Ritchie RF, et al. J Clin Lab Anal. 2004;18(2):148-52. doi: 10.1002/jcla.20013. J Clin Lab Anal. 2004. PMID: 15065216 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials
Miscellaneous