Mechanism of V(D)J recombination - PubMed (original) (raw)

Review

Mechanism of V(D)J recombination

M Bogue et al. Curr Opin Immunol. 1996 Apr.

Abstract

V(D)J recombination can be separated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year. Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved in both V(D)J recombination and double-strand break repair.

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