Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus - PubMed (original) (raw)
Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus
O K Hassani et al. Neuroscience. 1996 May.
Abstract
Electrophysiological records of unit activity were used to compare the effects of excitotoxic pallidal lesions and 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the discharge rates and patterns of the subthalamic neurons. Removal of the pallidal input induced a slight, but statistically significant, increase (19.5%) in the discharge rate and no change in the firing pattern when compared to control animals. The rats with a dopaminergic lesion showed greater increase (105.7%) while the firing pattern activity of the subthalamic neurons became more irregular, with burst. These results indicate that the increased activity of the subthalamic neurons following a midbrain dopaminergic lesion cannot be due solely to inhibition-disinhibition involving the striato-pallido-subthalamic pathway and induced by the striatal dopaminergic depletion.
Similar articles
- GABAergic control of rat substantia nigra dopaminergic neurons: role of globus pallidus and substantia nigra pars reticulata.
Celada P, Paladini CA, Tepper JM. Celada P, et al. Neuroscience. 1999 Mar;89(3):813-25. doi: 10.1016/s0306-4522(98)00356-x. Neuroscience. 1999. PMID: 10199615 - Pallidal control of substantia nigra dopaminergic neuron firing pattern and its relation to extracellular neostriatal dopamine levels.
Lee CR, Abercrombie ED, Tepper JM. Lee CR, et al. Neuroscience. 2004;129(2):481-9. doi: 10.1016/j.neuroscience.2004.07.034. Neuroscience. 2004. PMID: 15501605 - Dopaminergic control of the globus pallidus through activation of D2 receptors and its impact on the electrical activity of subthalamic nucleus and substantia nigra reticulata neurons.
Mamad O, Delaville C, Benjelloun W, Benazzouz A. Mamad O, et al. PLoS One. 2015 Mar 5;10(3):e0119152. doi: 10.1371/journal.pone.0119152. eCollection 2015. PLoS One. 2015. PMID: 25742005 Free PMC article. - GABAergic control of substantia nigra dopaminergic neurons.
Tepper JM, Lee CR. Tepper JM, et al. Prog Brain Res. 2007;160:189-208. doi: 10.1016/S0079-6123(06)60011-3. Prog Brain Res. 2007. PMID: 17499115 Review. - Neuroprotective effect of chronic inactivation of the subthalamic nucleus in a rat model of Parkinson's disease.
Piallat B, Benazzouz A, Benabid AL. Piallat B, et al. J Neural Transm Suppl. 1999;55:71-7. doi: 10.1007/978-3-7091-6369-6_7. J Neural Transm Suppl. 1999. PMID: 10335494 Review.
Cited by
- Differences in subthalamic oscillatory activity in the two hemispheres associated with severity of Parkinson's disease.
Zhao X, Zhuang P, Hallett M, Zhang Y, Li J, Wen Y, Li J, Wang Y, Hu Y, Li Y. Zhao X, et al. Front Aging Neurosci. 2023 Aug 28;15:1185348. doi: 10.3389/fnagi.2023.1185348. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37700815 Free PMC article. - Optogenetic Globus Pallidus Stimulation Improves Motor Deficits in 6-Hydroxydopamine-Lesioned Mouse Model of Parkinson's Disease.
Di Bisceglie Caballero S, Ces A, Liberge M, Ambroggi F, Amalric M, Ouagazzal AM. Di Bisceglie Caballero S, et al. Int J Mol Sci. 2023 Apr 27;24(9):7935. doi: 10.3390/ijms24097935. Int J Mol Sci. 2023. PMID: 37175643 Free PMC article. - Subthalamic and nigral neurons are differentially modulated during parkinsonian gait.
Gulberti A, Wagner JR, Horn MA, Reuss JH, Heise M, Koeppen JA, Pinnschmidt HO, Westphal M, Engel AK, Gerloff C, Sharott A, Hamel W, Moll CKE, Pötter-Nerger M. Gulberti A, et al. Brain. 2023 Jul 3;146(7):2766-2779. doi: 10.1093/brain/awad006. Brain. 2023. PMID: 36730026 Free PMC article. - Excitatory deep brain stimulation quenches beta oscillations arising in a computational model of the subthalamo-pallidal loop.
Alavi SM, Mirzaei A, Valizadeh A, Ebrahimpour R. Alavi SM, et al. Sci Rep. 2022 May 12;12(1):7845. doi: 10.1038/s41598-022-10084-4. Sci Rep. 2022. PMID: 35552409 Free PMC article. - Analysis of morphological and neurochemical changes in subthalamic nucleus neurons in response to a unilateral 6-OHDA lesion of the substantia nigra in adult rats.
Sedaghat K, Gundlach AL, Finkelstein DI. Sedaghat K, et al. IBRO Neurosci Rep. 2021 Jan 20;10:96-103. doi: 10.1016/j.ibneur.2021.01.002. eCollection 2021 Jun. IBRO Neurosci Rep. 2021. PMID: 33842916 Free PMC article.