Paracrine interactions of BDNF involving NGF-dependent embryonic sensory neurons - PubMed (original) (raw)
Paracrine interactions of BDNF involving NGF-dependent embryonic sensory neurons
M Robinson et al. Mol Cell Neurosci. 1996 Feb.
Abstract
The expression of BDNF mRNA by a proportion of embryonic dorsal root ganglion neurons has led to the proposal that BDNF acts by an autocrine loop on these neurons. To clarify the role of BDNF expression in developing sensory neurons, we measured the level of BDNF mRNA in purified populations of cranial sensory neurons that depend on either NGF or BDNF for survival. When neuronal death is taking place, the highest levels of BDNF mRNA were detected in NGF-dependent cutaneous sensory neurons. BDNF mRNA was expressed at lower levels in BDNF-dependent cutaneous sensory neurons and was undetectable in BDNF-dependent proprioceptive neurons. In coculture, NGF-dependent neurons promoted the survival of BDNF-dependent neurons by the production and release of BDNF. Depolarizing levels of KCl increased the expression of BDNF mRNA in cultured sensory neurons and this effect was partially inhibited by calcium channel antagonists. Our results suggest that during the phase of naturally occurring neuronal death, BDNF acts by a paracrine mechanism in sensory neurons and that BDNF expression is regulated by neural activity.
Similar articles
- p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor.
Hamanoue M, Middleton G, Wyatt S, Jaffray E, Hay RT, Davies AM. Hamanoue M, et al. Mol Cell Neurosci. 1999 Jul;14(1):28-40. doi: 10.1006/mcne.1999.0770. Mol Cell Neurosci. 1999. PMID: 10433815 - Leukemia inhibitory factor and neurotrophins support overlapping populations of rat nodose sensory neurons in culture.
Thaler CD, Suhr L, Ip N, Katz DM. Thaler CD, et al. Dev Biol. 1994 Feb;161(2):338-44. doi: 10.1006/dbio.1994.1035. Dev Biol. 1994. PMID: 8313987 - Differential regulation of neurotrophin expression in basal forebrain astrocytes by neuronal signals.
Wu H, Friedman WJ, Dreyfus CF. Wu H, et al. J Neurosci Res. 2004 Apr 1;76(1):76-85. doi: 10.1002/jnr.20060. J Neurosci Res. 2004. PMID: 15048931 - Neurotrophins as in vitro growth cone guidance molecules for embryonic sensory neurons.
Paves H, Saarma M. Paves H, et al. Cell Tissue Res. 1997 Nov;290(2):285-97. doi: 10.1007/s004410050933. Cell Tissue Res. 1997. PMID: 9321690 Review. - Neurotrophic factors and neuronal death.
Thoenen H, Barde YA, Davies AM, Johnson JE. Thoenen H, et al. Ciba Found Symp. 1987;126:82-95. doi: 10.1002/9780470513422.ch6. Ciba Found Symp. 1987. PMID: 3556091 Review.
Cited by
- Role of Neurotrophins in Orofacial Pain Modulation: A Review of the Latest Discoveries.
Bonomini F, Favero G, Castrezzati S, Borsani E. Bonomini F, et al. Int J Mol Sci. 2023 Aug 4;24(15):12438. doi: 10.3390/ijms241512438. Int J Mol Sci. 2023. PMID: 37569811 Free PMC article. Review. - Extraocular Motor System Exhibits a Higher Expression of Neurotrophins When Compared with Other Brainstem Motor Systems.
Hernández RG, Silva-Hucha S, Morcuende S, de la Cruz RR, Pastor AM, Benítez-Temiño B. Hernández RG, et al. Front Neurosci. 2017 Jul 11;11:399. doi: 10.3389/fnins.2017.00399. eCollection 2017. Front Neurosci. 2017. PMID: 28744196 Free PMC article. - Functional Diversity of Neurotrophin Actions on the Oculomotor System.
Benítez-Temiño B, Davis-López de Carrizosa MA, Morcuende S, Matarredona ER, de la Cruz RR, Pastor AM. Benítez-Temiño B, et al. Int J Mol Sci. 2016 Dec 1;17(12):2016. doi: 10.3390/ijms17122016. Int J Mol Sci. 2016. PMID: 27916956 Free PMC article. Review. - Diffusive transfer between two intensely interacting cells with limited surface kinetics.
Labowsky M, Fahmy TM. Labowsky M, et al. Chem Eng Sci. 2012 May 28;74:114-123. doi: 10.1016/j.ces.2012.02.001. Epub 2012 Feb 6. Chem Eng Sci. 2012. PMID: 22485051 Free PMC article. - Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development.
Harlow DE, Yang H, Williams T, Barlow LA. Harlow DE, et al. Dev Dyn. 2011 Feb;240(2):309-23. doi: 10.1002/dvdy.22527. Epub 2011 Jan 5. Dev Dyn. 2011. PMID: 21246648 Free PMC article.