Developing brain cells produce factors capable of inducing the HT7 antigen, a blood-brain barrier-specific molecule, in chick endothelial cells - PubMed (original) (raw)
Developing brain cells produce factors capable of inducing the HT7 antigen, a blood-brain barrier-specific molecule, in chick endothelial cells
E Ikeda et al. Neurosci Lett. 1996.
Abstract
Homeostasis of the neural microenvironment is maintained by the blood-brain barrier (BBB). To analyze the molecular mechanisms by which the BBB is induced during embryonic development, we have taken advantage of an in vivo model of BBB induction based on the expression of the HT7 cell surface protein. This protein is a transmembrane glycoprotein of the immunoglobulin superfamily. It is expressed in the chick BBB-forming endothelial cells, but not in peripheral endothelial cells. Here we show that the HT7 protein is induced in vessels which had vascularized a quail embryonic brain graft transplanted in the coelomic cavity of chick embryo. The quail brain graft was vascularized by both chick and quail-derived vessels. All chick host-derived vessels in the brain transplant were found to express HT7 while the neighboring chick vessels were negative. We conclude that the invading host endothelial cells differentiated into BBB-forming vessels under the influence of developing quail brain cells. This model reproduces the BBB induction during development. It may be useful for further approaches to study the molecular mechanisms involved in BBB induction.
Similar articles
- Induction of the blood-brain barrier marker neurothelin/HT7 in endothelial cells by a variety of tumors in chick embryos.
Papoutsi M, Kurz H, Schächtele C, Marmé D, Christ B, Pröls F, Wilting J. Papoutsi M, et al. Histochem Cell Biol. 2000 Feb;113(2):105-13. doi: 10.1007/s004180050013. Histochem Cell Biol. 2000. PMID: 10766263 - Chorioallantoic membrane (CAM) vessels do not respond to blood-brain barrier (BBB) induction.
Holash JA, Stewart PA. Holash JA, et al. Adv Exp Med Biol. 1993;331:223-8. doi: 10.1007/978-1-4615-2920-0_35. Adv Exp Med Biol. 1993. PMID: 8333337 No abstract available. - Developmental changes of HT7 expression in the microvessels of the chick embryo brain.
Bertossi M, Girolamo F, Errede M, Benagiano V, Virgintino D, Roncali L. Bertossi M, et al. Anat Embryol (Berl). 2002 Jun;205(3):229-33. doi: 10.1007/s00429-002-0245-x. Epub 2002 Apr 16. Anat Embryol (Berl). 2002. PMID: 12107493 - The blood-brain barrier: morphology, molecules, and neurothelin.
Schlosshauer B. Schlosshauer B. Bioessays. 1993 May;15(5):341-6. doi: 10.1002/bies.950150508. Bioessays. 1993. PMID: 8102053 Review. - Molecular anatomy of the blood-brain barrier as defined by immunocytochemistry.
Dermietzel R, Krause D. Dermietzel R, et al. Int Rev Cytol. 1991;127:57-109. doi: 10.1016/s0074-7696(08)60692-0. Int Rev Cytol. 1991. PMID: 1880006 Review.
Cited by
- Corticosteroids are unable to protect against pseudorabies virus-induced tissue damage in the developing brain.
Clase AC, Banfield BW. Clase AC, et al. J Virol. 2003 Apr;77(8):4979-84. doi: 10.1128/jvi.77.8.4979-4984.2003. J Virol. 2003. PMID: 12663804 Free PMC article. - Historical and current perspectives on blood endothelial cell heterogeneity in the brain.
Matsuoka RL, Buck LD, Vajrala KP, Quick RE, Card OA. Matsuoka RL, et al. Cell Mol Life Sci. 2022 Jun 20;79(7):372. doi: 10.1007/s00018-022-04403-1. Cell Mol Life Sci. 2022. PMID: 35726097 Free PMC article. Review. - Novel insights into the development and maintenance of the blood-brain barrier.
Engelhardt B, Liebner S. Engelhardt B, et al. Cell Tissue Res. 2014 Mar;355(3):687-99. doi: 10.1007/s00441-014-1811-2. Epub 2014 Mar 4. Cell Tissue Res. 2014. PMID: 24590145 Free PMC article. Review. - "You Shall Not Pass"-tight junctions of the blood brain barrier.
Bauer HC, Krizbai IA, Bauer H, Traweger A. Bauer HC, et al. Front Neurosci. 2014 Dec 3;8:392. doi: 10.3389/fnins.2014.00392. eCollection 2014. Front Neurosci. 2014. PMID: 25520612 Free PMC article. Review. - Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.
Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E. Koto T, et al. Am J Pathol. 2007 Apr;170(4):1389-97. doi: 10.2353/ajpath.2007.060693. Am J Pathol. 2007. PMID: 17392177 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources