Problems and priorities for controlling opportunistic pathogens with new antimicrobial strategies; an overview of current literature - PubMed (original) (raw)
Review
. 1996 Apr;283(4):431-65.
doi: 10.1016/s0934-8840(96)80122-8.
J J Cebra, J Beuth, R Fuller, P J Heidt, T Midvedt, C E Nord, P Nieuwenhuis, W L Manson, G Pulverer, V C Rusch, R Tanaka, D van der Waaij, R I Walker, C L Wells
Affiliations
- PMID: 8737943
- DOI: 10.1016/s0934-8840(96)80122-8
Review
Problems and priorities for controlling opportunistic pathogens with new antimicrobial strategies; an overview of current literature
B A Araneo et al. Zentralbl Bakteriol. 1996 Apr.
Abstract
An International Study Group on New Antimicrobial Strategies (ISGNAS) has been formed in response to the recognition that development of microbial resistance to antibiotics is becoming a serious, world-wide problem. The group met in 1993 for the first time to discuss the feasibility of developing rational alternatives to the use of antibiotics and prepared, as a result, a comprehensive overview of normal (physiological) mechanisms involved in the control of potentially pathogenic (oppotunistic) microorganisms. One objective of ISGNAS is to understand the conditions which allow opportunistic microbes present among the symbionts to cause an infection. There is a need for more coherent information concerning the habitat, growth requirements and host and pathogen properties which allow opportunistic pathogens to cause life-threatening infections. In particular, information is urgently being sought to understand the complexity of the interactions between the vast number of microbial species, and the interactions between the microbes and their host. Another goal is to inspire and enable basic and clinical research that will lead to the development of new therapies for regulating colonization, translocation and infection by opportunistic micro-organisms in patients during periods of decreased resistance. With a sufficient amount of knowledge of how healthy individuals keep opportunistic micro-organisms under control, it may become feasible for physicians to maintain host resistance and inter-microbial factors involved in the containment of opportunistic microbes. Therapies aimed at boostering natural resistance mechanisms will be of critical importance to individuals whose resistance has been compromised as a result of another clinical condition.
Similar articles
- Role of human microflora in health and disease.
Tancrède C. Tancrède C. Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):1012-5. doi: 10.1007/BF01967791. Eur J Clin Microbiol Infect Dis. 1992. PMID: 1295753 Review. - Hidden killers: persistence of opportunistic fungal pathogens in the human host.
d'Enfert C. d'Enfert C. Curr Opin Microbiol. 2009 Aug;12(4):358-64. doi: 10.1016/j.mib.2009.05.008. Epub 2009 Jun 21. Curr Opin Microbiol. 2009. PMID: 19541532 Review. - Host-recognition of pathogens and commensals in the mammalian intestine.
Rossi O, van Baarlen P, Wells JM. Rossi O, et al. Curr Top Microbiol Immunol. 2013;358:291-321. doi: 10.1007/82_2011_191. Curr Top Microbiol Immunol. 2013. PMID: 22179258 Review. - Pulmonary defense mechanisms against opportunistic fungal pathogens.
Waldorf AR. Waldorf AR. Immunol Ser. 1989;47:243-71. Immunol Ser. 1989. PMID: 2490078 Review. - [Antimicrobial preparations and normal microflora. Problems and possible ways of their solving].
Shenderov BA. Shenderov BA. Antibiot Khimioter. 1988 Dec;33(12):921-6. Antibiot Khimioter. 1988. PMID: 3245709 Russian. No abstract available.
Cited by
- Influence of zinc bacitracin and Bacillus licheniformis on microbial intestinal functions in weaned piglets.
Collinder E, Cardona ME, Berge GN, Norin E, Stern S, Midtvedt T. Collinder E, et al. Vet Res Commun. 2003 Oct;27(7):513-26. doi: 10.1023/a:1026043623194. Vet Res Commun. 2003. PMID: 14609263 - A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem.
Hooper LV, Xu J, Falk PG, Midtvedt T, Gordon JI. Hooper LV, et al. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9833-8. doi: 10.1073/pnas.96.17.9833. Proc Natl Acad Sci U S A. 1999. PMID: 10449780 Free PMC article. - Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology.
Falk PG, Hooper LV, Midtvedt T, Gordon JI. Falk PG, et al. Microbiol Mol Biol Rev. 1998 Dec;62(4):1157-70. doi: 10.1128/MMBR.62.4.1157-1170.1998. Microbiol Mol Biol Rev. 1998. PMID: 9841668 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Miscellaneous